Ji Hong, Cai Jianghong, Gan Nana, Wang Zhaohua, Wu Liyang, Li Guorong, Yi Tao
Key Laboratory of Molecular Target & Clinical Pharmacology, School of Pharmaceutical Sciences & the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
School of Basic Sciences, Guangzhou Medical University, Guangzhou, 511436, People's Republic of China.
Chem Cent J. 2018 Dec 19;12(1):136. doi: 10.1186/s13065-018-0510-6.
A facile and efficient palladium-catalyzed borylation of aryl (pseudo)halides at room temperature has been developed. Arylboronic esters were expeditiously assembled in good yields and with a broad substrate scope and good functional group compatibility. This approach has been successfully applied to the one-pot two-step borylation/Suzuki-Miyaura cross-coupling reaction, providing a concise access to biaryl compounds from readily available aryl halides. Furthermore, a parallel synthesis of biaryl analogs is accomplished at room temperature using the strategy, which enhances the practical usefulness of this method.
已开发出一种在室温下简便高效的钯催化芳基（拟）卤化物硼化反应。芳基硼酸酯能快速以良好产率组装而成，具有广泛的底物范围和良好的官能团兼容性。该方法已成功应用于一锅两步硼化/铃木-宫浦交叉偶联反应，可从易得的芳基卤化物简洁地制备联芳基化合物。此外，利用该策略在室温下完成了联芳基类似物的平行合成，提高了该方法的实际应用价值。
