Faculty of Applied Sciences, Ton Duc Thang University, Ho Chi Minh City, Vietnam.
Division of Radiation Oncology, Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan.
J Cell Physiol. 2019 Jun;234(6):8443-8454. doi: 10.1002/jcp.27769. Epub 2018 Nov 22.
Engineering/reprogramming differentiated adult somatic cells to gain the ability to differentiate into any type of cell lineage are called as induced pluripotent stem cells (iPSCs). Offering unlimited self-renewal and differentiation potential, these iPSC are aspired to meet the growing demands in the field of regenerative medicine, tissue engineering, disease modeling, nanotechnology, and drug discovery. Biomaterial fabrication with the rapid evolution of technology increased their versatility and utility in regenerative medicine and tissue engineering, revolutionizing the stem cell biology research with the property to guide the process of proliferation, differentiation, and morphogenesis. Combining traditional culture platforms of iPSC with biomaterials aids to overcome the limitations associated with derivation, proliferation, and maturation, thereby could improve the clinical translation of iPSC. The present review discusses in brief about the reprogramming techniques for the derivation iPSC and details on several biomaterial guided differentiation of iPSC to different cell types with specific relevance to tissue engineering/regenerative medicine.
将分化的成年体细胞工程/重编程为获得分化为任何类型细胞谱系的能力的细胞被称为诱导多能干细胞（iPSC）。这些 iPSC 具有无限的自我更新和分化潜力，有望满足再生医学、组织工程、疾病建模、纳米技术和药物发现领域不断增长的需求。随着技术的快速发展，生物材料制造增加了它们在再生医学和组织工程中的多功能性和实用性，通过引导增殖、分化和形态发生过程的特性，彻底改变了干细胞生物学研究。将 iPSC 与生物材料的传统培养平台相结合，有助于克服与衍生、增殖和成熟相关的局限性，从而可以提高 iPSC 的临床转化。本综述简要讨论了 iPSC 的重编程技术，并详细介绍了几种生物材料指导的 iPSC 向不同细胞类型的分化，与组织工程/再生医学具有特定相关性。
