用于组织工程应用的自修复超分子水凝胶。
Self-Healing Supramolecular Hydrogels for Tissue Engineering Applications.
机构信息
Macromolecular Science and Engineering Center, University of Michigan, Ann Arbor, 48109, MI, USA.
Biologic and Materials Science, University of Michigan, Ann Arbor, 48109, MI, USA.
出版信息
Macromol Biosci. 2019 Jan;19(1):e1800313. doi: 10.1002/mabi.201800313. Epub 2018 Nov 22.
Abstract
Self-healing supramolecular hydrogels have emerged as a novel class of biomaterials that combine hydrogels with supramolecular chemistry to develop highly functional biomaterials with advantages including native tissue mimicry, biocompatibility, and injectability. These properties are endowed by the reversibly cross-linked polymer network of the hydrogel. These hydrogels have great potential for realizing yet to be clinically translated tissue engineering therapies. This review presents methods of self-healing supramolecular hydrogel formation and their uses in tissue engineering as well as future perspectives.
摘要
自修复超分子水凝胶作为一类新型生物材料，结合了水凝胶和超分子化学，开发出具有天然组织模拟、生物相容性和可注射性等优点的高度功能性生物材料。这些特性是由水凝胶的可反复交联聚合物网络赋予的。这些水凝胶在实现尚未转化为临床的组织工程治疗方面具有巨大潜力。本文综述了自修复超分子水凝胶的形成方法及其在组织工程中的应用，并对未来的发展前景进行了展望。
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本文引用的文献
1
Polypeptide hydrogels via a unique assembly mechanism.通过独特组装机制形成的多肽水凝胶
Soft Matter. 2005 May 27;1(1):28-35. doi: 10.1039/b500307e.
2
Hydrogen bonded and ionically crosslinked high strength hydrogels exhibiting Ca-triggered shape memory properties and volume shrinkage for cell detachment.具有氢键和离子交联的高强度水凝胶，展现出钙触发的形状记忆特性以及用于细胞脱离的体积收缩。
J Mater Chem B. 2015 Aug 14;3(30):6347-6354. doi: 10.1039/c5tb00781j. Epub 2015 Jul 9.
3
A Rapidly Self-Healing Host-Guest Supramolecular Hydrogel with High Mechanical Strength and Excellent Biocompatibility.一种具有快速自修复能力、高强度机械性能和良好生物相容性的主客体超分子水凝胶。
Angew Chem Int Ed Engl. 2018 Jul 16;57(29):9008-9012. doi: 10.1002/anie.201804400. Epub 2018 Jun 19.
4
Accelerated wound healing by injectable star poly(ethylene glycol)-b-poly(propylene sulfide) scaffolds loaded with poorly water-soluble drugs.可注射星形聚乙二醇-b-聚丙硫醚支架负载疏水性药物加速创伤愈合。
J Control Release. 2018 Jul 28;282:156-165. doi: 10.1016/j.jconrel.2018.05.006. Epub 2018 May 9.
5
Polyhistidine-Based Metal Coordination Hydrogels with Physiologically Relevant pH Responsiveness and Enhanced Stability through a Novel Synthesis.基于多组氨酸的金属配位水凝胶具有生理相关的 pH 响应性，并通过新颖的合成方法提高了稳定性。
Macromol Rapid Commun. 2018 Jun;39(11):e1800109. doi: 10.1002/marc.201800109. Epub 2018 May 3.
6
Degradable 3D-Printed Hydrogels Based on Star-Shaped Copolypeptides.基于星型共聚多肽的可降解 3D 打印水凝胶。
Biomacromolecules. 2018 Jul 9;19(7):2691-2699. doi: 10.1021/acs.biomac.8b00299. Epub 2018 Apr 24.
7
Three-dimensional extrusion bioprinting of single- and double-network hydrogels containing dynamic covalent crosslinks.三维挤压式生物打印单网络和双网络水凝胶，其中包含动态共价交联。
J Biomed Mater Res A. 2018 Apr;106(4):865-875. doi: 10.1002/jbm.a.36323. Epub 2018 Jan 23.
8
Controlling protein activity by dynamic recruitment on a supramolecular polymer platform.通过在超分子聚合物平台上的动态募集来控制蛋白质活性。
Nat Commun. 2018 Jan 4;9(1):65. doi: 10.1038/s41467-017-02559-0.
9
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Biomacromolecules. 2018 Feb 12;19(2):288-297. doi: 10.1021/acs.biomac.7b01133. Epub 2018 Jan 18.
10
The design of reversible hydrogels to capture extracellular matrix dynamics.用于捕捉细胞外基质动态变化的可逆水凝胶设计。
Nat Rev Mater. 2016;1. doi: 10.1038/natrevmats.2015.12. Epub 2016 Feb 2.
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