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亚急性甲状腺炎背景下的结肠炎:先有鸡还是先有蛋。

colitis in the setting of subacute thyroiditis: the chicken or the egg.

作者信息

Mathew Jacob

机构信息

Department of Aviation Medicine, Evans US Army Hospital, Fort Carson, Colorado, USA.

出版信息

BMJ Case Rep. 2018 Dec 18;11(1):e226711. doi: 10.1136/bcr-2018-226711.

DOI:10.1136/bcr-2018-226711
PMID:30567894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6303558/
Abstract

Subacutethyroiditis is a self-limited inflammatory condition commonly of viral aetiology, that manifests through phases of thyroid hormone changes over a 6-8 month period. A 24-year-old active duty military man, undergoing treatment for recurrent infection, presented for clinical evaluation and was found to have a thyroid stimulating hormone level of 0.003 mg/dL. Further labs revealed a normal T4, elevated T3 at 5.0 pg/mL and elevated C reactive protein at 3.69 mg/L. The patient was followed with monthly labs and the abnormal thyroid stimulating hormone and triiodothyronine levels resolved after the completion of his treatment. While subacute thyroiditis has historically been due to viral causes, rarely do we see this condition associated with an intestinal bacterial source.

摘要

亚急性甲状腺炎是一种通常由病毒病因引起的自限性炎症性疾病,在6至8个月的时间内通过甲状腺激素变化阶段表现出来。一名24岁的现役军人正在接受反复感染的治疗,前来进行临床评估,发现其促甲状腺激素水平为0.003mg/dL。进一步的实验室检查显示T4正常,T3升高至5.0pg/mL,C反应蛋白升高至3.69mg/L。该患者每月进行实验室检查,在完成治疗后,异常的促甲状腺激素和三碘甲状腺原氨酸水平恢复正常。虽然亚急性甲状腺炎历来是由病毒引起的,但我们很少看到这种疾病与肠道细菌来源有关。

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本文引用的文献

1
Asymptomatic thyroiditis presenting as pyrexia of unknown origin: a case report.表现为不明原因发热的无症状甲状腺炎:一例报告
J Med Case Rep. 2018 Feb 23;12(1):51. doi: 10.1186/s13256-018-1590-6.
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Alterations of the Gut Microbiota in Hashimoto's Thyroiditis Patients.桥本甲状腺炎患者肠道微生物群的改变。
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Fine-Needle Aspiration of De Quervain's Thyroiditis (Subacute Granulomatous Thyroiditis): A Cytological Review of 20 Cases.亚急性肉芽肿性甲状腺炎(德奎尔万甲状腺炎)的细针穿刺抽吸:20例细胞学回顾
J Clin Diagn Res. 2017 Aug;11(8):EC09-EC11. doi: 10.7860/JCDR/2017/26054.10355. Epub 2017 Aug 1.
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The microbiota and autoimmunity: Their role in thyroid autoimmune diseases.微生物群与自身免疫:它们在甲状腺自身免疫性疾病中的作用。
Clin Immunol. 2017 Oct;183:63-74. doi: 10.1016/j.clim.2017.07.001. Epub 2017 Jul 6.
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Subacute thyroiditis: clinical presentation and long term outcome.亚急性甲状腺炎:临床表现与长期转归。
Int J Endocrinol. 2014;2014:794943. doi: 10.1155/2014/794943. Epub 2014 Apr 3.
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Ultrasound findings of subacute thyroiditis: a single institution retrospective review.亚急性甲状腺炎的超声表现:单机构回顾性研究
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Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association.成人甲状腺功能减退症临床实践指南:由美国临床内分泌医师学会和美国甲状腺协会共同赞助。
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Significant role of serum CRP in differentiating inflammatory from non-inflammatory causes of thyrotoxicosis.血清C反应蛋白在区分甲状腺毒症的炎症性与非炎症性病因中起重要作用。
Indian J Endocrinol Metab. 2012 Nov;16(6):976-81. doi: 10.4103/2230-8210.103002.
10
Clinical review: Central hypothyroidism: pathogenic, diagnostic, and therapeutic challenges.临床综述:中枢性甲状腺功能减退症:发病机制、诊断和治疗挑战。
J Clin Endocrinol Metab. 2012 Sep;97(9):3068-78. doi: 10.1210/jc.2012-1616. Epub 2012 Jul 31.