Division of Cardiology, Nephrology, Pulmonology and Neurology, Department of Internal Medicine, Asahikawa Medical University.
Department of Cardiology, Rumoi City Hospital.
Circ J. 2019 Jan 25;83(2):481-484. doi: 10.1253/circj.CJ-18-0734. Epub 2018 Dec 18.
Although we and others have reported cases of patients with Anderson-Fabry disease (AFD) complicated by coronary spastic angina (CSA), the prevalence of CSA in these patients remains unknown.
We performed the acetylcholine-induced provocation test, according to the Japanese guidelines for the diagnosis and treatment of patients with CSA, in 9 consecutive patients having 5 independent AFD pedigrees. Coronary spasms were provoked in conjunction with symptoms and ECG ischemic changes in 8 of 9 (89%) patients with AFD.
We found an unexpectedly high prevalence of CSA in patients with AFD.
虽然我们和其他人已经报告了伴有安德森-法布里病（AFD）的患者发生冠状动脉痉挛性心绞痛（CSA）的病例，但这些患者中 CSA 的患病率尚不清楚。
我们按照日本 CSA 患者诊断和治疗指南，对 9 例具有 5 个独立 AFD 家系的患者进行了乙酰胆碱激发试验。9 例 AFD 患者中的 8 例（89%）在出现症状和心电图缺血改变的同时诱发了冠状动脉痉挛。
我们发现 AFD 患者中 CSA 的患病率出乎意料地高。
