Lin Jialing, Yao Zhenjiang
Department of Epidemiology and Health Statistics, School of Public Health, Guangdong Pharmaceutical University, Guangzhou, China.
Front Pediatr. 2018 Dec 5;6:384. doi: 10.3389/fped.2018.00384. eCollection 2018.
We aim to assess the correlation of multidrug-resistant (MDR ) carriage between mothers and their newborn infants. We conducted a prospective cohort study of mothers and their newborn infants in two hospitals in Shenzhen, China, from August to November 2015. We collected demographic and clinical information from mothers and newborn infants by face-to-face questionnaires and medical datasets. Serial swabs were collected from mothers and their newborn infants for further experiments. Maternal-infant correlation was assessed using the Poisson regression model. The prevalence of MDR vaginal carriage in mothers was 4.7% (86/1834). The incidence of MDR carriage in newborn infants was 1.3% (23/1834). The adjusted relative risk and 95% confidence interval of maternal-infant MDR carriage was 7.63 (2.99-19.49). Six MDR maternal-infant pairs were concordant. The phenotypic and molecular characteristics of MDR isolates were similar between mothers and their newborn infants. MDR vaginal carriage in mothers was associated with an increased risk for MDR carriage in their newborn infants.
我们旨在评估母亲与其新生儿之间多重耐药（MDR）携带情况的相关性。2015年8月至11月，我们在中国深圳的两家医院对母亲及其新生儿进行了一项前瞻性队列研究。我们通过面对面问卷调查和医疗数据集收集了母亲和新生儿的人口统计学和临床信息。从母亲及其新生儿身上采集系列拭子用于进一步实验。使用泊松回归模型评估母婴相关性。母亲中MDR阴道携带率为4.7%（86/1834）。新生儿中MDR携带率为1.3%（23/1834）。母婴MDR携带的校正相对风险和95%置信区间为7.63（2.99 - 19.49）。有6对母婴MDR情况一致。母亲与其新生儿之间MDR分离株的表型和分子特征相似。母亲的MDR阴道携带与其新生儿MDR携带风险增加有关。
