益生菌对降低住院患者感染率无影响：一项真实世界经验
No Impact of Probiotics to Reduce Infection in Hospitalized Patients: A Real-world Experience.
作者信息
Box Maggie J, Ortwine Kristine N, Goicoechea Miguel
机构信息
Department of Pharmacy, Scripps Health, San Diego, California.
Division of Infectious Diseases, Scripps Health, San Diego, California.
出版信息
Open Forum Infect Dis. 2018 Dec 13;5(12):ofy192. doi: 10.1093/ofid/ofy192. eCollection 2018 Dec.
Abstract
We assessed the effectiveness of a Lactobacillus probiotic on rates of health care facility-onset infection (HO-CDI) in patients receiving antibiotics. A total of 1576 patients were evaluated. There was no difference in the HO-CDI incidence between those who received probiotics and those who did not (1.8% vs 0.9%; = .16).
摘要
我们评估了一种乳酸杆菌益生菌对接受抗生素治疗的患者发生医疗机构获得性感染（HO-CDI）发生率的影响。总共评估了1576名患者。接受益生菌治疗的患者与未接受益生菌治疗的患者之间的HO-CDI发生率没有差异（1.8%对0.9%；P = 0.16）。
相似文献
1
No Impact of Probiotics to Reduce Infection in Hospitalized Patients: A Real-world Experience.益生菌对降低住院患者感染率无影响：一项真实世界经验
Open Forum Infect Dis. 2018 Dec 13;5(12):ofy192. doi: 10.1093/ofid/ofy192. eCollection 2018 Dec.
2
A Single-Center, Retrospective Cohort Study Evaluating the Use of Probiotics for the Prevention of Hospital-Onset Infection in Hospitalized Patients Receiving Intravenous Antibiotics.一项单中心回顾性队列研究，评估益生菌在接受静脉抗生素治疗的住院患者中预防医院获得性感染的应用情况。
Hosp Pharm. 2023 Feb;58(1):57-61. doi: 10.1177/00185787221120153. Epub 2022 Aug 25.
3
Implementation of Global Strategies to Prevent Hospital-Onset Clostridium difficile Infection: Targeting Proton Pump Inhibitors and Probiotics.实施全球预防医院获得性艰难梭菌感染的策略：以质子泵抑制剂和益生菌为目标
Ann Pharmacother. 2017 Oct;51(10):848-854. doi: 10.1177/1060028017694050. Epub 2017 Aug 18.
4
The Effect of Lactobacillus plantarum 299v on the Incidence of Clostridium difficile Infection in High Risk Patients Treated with Antibiotics.植物乳杆菌299v对接受抗生素治疗的高危患者艰难梭菌感染发生率的影响。
Nutrients. 2015 Dec 4;7(12):10179-88. doi: 10.3390/nu7125526.
5
Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection: A Systematic Review With Meta-Regression Analysis.及时使用益生菌可预防住院成人艰难梭菌感染：系统评价与荟萃回归分析。
Gastroenterology. 2017 Jun;152(8):1889-1900.e9. doi: 10.1053/j.gastro.2017.02.003. Epub 2017 Feb 10.
6
The Cost-efficiency and Care Effectiveness of Probiotic Administration with Antibiotics to Prevent Hospital-Acquired Clostridium difficile Infection.抗生素联合益生菌预防医院获得性艰难梭菌感染的成本效益及护理效果
Qual Manag Health Care. 2016 Oct/Dec;25(4):238-243. doi: 10.1097/QMH.0000000000000110.
7
Is primary prevention of Clostridium difficile infection possible with specific probiotics?特定益生菌可否用于艰难梭菌感染的一级预防？
Int J Infect Dis. 2012 Nov;16(11):e786-92. doi: 10.1016/j.ijid.2012.06.005. Epub 2012 Aug 3.
8
Probiotics are effective at preventing Clostridium difficile-associated diarrhea: a systematic review and meta-analysis.益生菌对预防艰难梭菌相关性腹泻有效：一项系统评价与荟萃分析。
Int J Gen Med. 2016 Feb 22;9:27-37. doi: 10.2147/IJGM.S98280. eCollection 2016.
9
Reduces the Incidence of Infection in Nephrology and Transplantation Ward-Results of One Year Extended Study.减少肾病和移植病房感染发生率——一年延伸研究结果。
Nutrients. 2018 Oct 24;10(11):1574. doi: 10.3390/nu10111574.
10
Modified Mouse Model of Clostridioides difficile Infection as a Platform for Probiotic Efficacy Studies.艰难梭菌感染改良小鼠模型作为益生菌疗效研究的平台。
Antimicrob Agents Chemother. 2019 Jun 24;63(7). doi: 10.1128/AAC.00111-19. Print 2019 Jul.
引用本文的文献
1
The Role of Probiotics in the Prevention of Infection in Patients with Chronic Kidney Disease.益生菌在慢性肾脏病患者感染预防中的作用
Nutrients. 2024 Feb 27;16(5):671. doi: 10.3390/nu16050671.
2
Role of probiotics in preventing infection in older adults: an integrative review.益生菌在预防老年人感染中的作用：一项综合综述。
Front Med (Lausanne). 2023 Aug 10;10:1219225. doi: 10.3389/fmed.2023.1219225. eCollection 2023.
3
Microbiome-Related and Infection Control Approaches to Primary and Secondary Prevention of Infections.微生物群相关及感染控制方法在感染一级和二级预防中的应用
Microorganisms. 2023 Jun 9;11(6):1534. doi: 10.3390/microorganisms11061534.
4
A Single-Center, Retrospective Cohort Study Evaluating the Use of Probiotics for the Prevention of Hospital-Onset Infection in Hospitalized Patients Receiving Intravenous Antibiotics.一项单中心回顾性队列研究，评估益生菌在接受静脉抗生素治疗的住院患者中预防医院获得性感染的应用情况。
Hosp Pharm. 2023 Feb;58(1):57-61. doi: 10.1177/00185787221120153. Epub 2022 Aug 25.
5
Impact of an automatic hospital probiotic protocol on () infection (CDI) rates and CDI antibiotic usage in a community hospital setting.自动医院益生菌方案对社区医院环境中艰难梭菌感染（CDI）发生率及CDI抗生素使用情况的影响。 （原文括号处内容缺失，翻译时按常见情况补充完整）
J Infect Prev. 2020 Mar;21(2):72-75. doi: 10.1177/1757177419892309. Epub 2019 Dec 20.
6
Lemon Exosome-like Nanoparticles-Manipulated Probiotics Protect Mice from Infection.柠檬外泌体样纳米颗粒操控的益生菌保护小鼠免受感染。
iScience. 2020 Sep 16;23(10):101571. doi: 10.1016/j.isci.2020.101571. eCollection 2020 Oct 23.
7
therapeutics: guidelines and beyond.治疗学：指南及其他
Ther Adv Infect Dis. 2019 Aug 13;6:2049936119868548. doi: 10.1177/2049936119868548. eCollection 2019 Jan-Dec.
8
Rhetoric or Rhetoric: Interpreting Cross-Sectional Data When There Are Disparate Control Groups.修辞学或修辞：存在不同对照组时对横断面数据的解读
Open Forum Infect Dis. 2019 Apr 25;6(4):ofz127. doi: 10.1093/ofid/ofz127. eCollection 2019 Apr.
本文引用的文献
1
Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA).临床实践指南：成人和儿童艰难梭菌感染：美国传染病学会（IDSA）和美国医疗保健流行病学学会（SHEA） 2017 年更新。
Clin Infect Dis. 2018 Mar 19;66(7):e1-e48. doi: 10.1093/cid/cix1085.
2
Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children.用于预防成人和儿童艰难梭菌相关性腹泻的益生菌
Cochrane Database Syst Rev. 2017 Dec 19;12(12):CD006095. doi: 10.1002/14651858.CD006095.pub4.
3
Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection: A Systematic Review With Meta-Regression Analysis.及时使用益生菌可预防住院成人艰难梭菌感染：系统评价与荟萃回归分析。
Gastroenterology. 2017 Jun;152(8):1889-1900.e9. doi: 10.1053/j.gastro.2017.02.003. Epub 2017 Feb 10.
4
Pathway to Prevention of Nosocomial Clostridium difficile Infection.预防医院内艰难梭菌感染的途径。
Clin Infect Dis. 2015 May 15;60 Suppl 2:S148-58. doi: 10.1093/cid/civ142.
5
Lactobacilli and bifidobacteria in the prevention of antibiotic-associated diarrhoea and Clostridium difficile diarrhoea in older inpatients (PLACIDE): a randomised, double-blind, placebo-controlled, multicentre trial.乳酸菌和双歧杆菌预防老年住院患者抗生素相关性腹泻和艰难梭菌相关性腹泻（PLACIDE）：一项随机、双盲、安慰剂对照、多中心试验。
Lancet. 2013 Oct 12;382(9900):1249-57. doi: 10.1016/S0140-6736(13)61218-0. Epub 2013 Aug 8.
6
Dose-response efficacy of a proprietary probiotic formula of Lactobacillus acidophilus CL1285 and Lactobacillus casei LBC80R for antibiotic-associated diarrhea and Clostridium difficile-associated diarrhea prophylaxis in adult patients.嗜酸乳杆菌 CL1285 和干酪乳杆菌 LBC80R 专利益生菌配方治疗成人抗生素相关性腹泻和艰难梭菌相关性腹泻预防的剂量反应疗效。
Am J Gastroenterol. 2010 Jul;105(7):1636-41. doi: 10.1038/ajg.2010.11. Epub 2010 Feb 9.
7
Probiotics for treatment of Clostridium difficile-associated colitis in adults.用于治疗成人艰难梭菌相关性结肠炎的益生菌
Cochrane Database Syst Rev. 2008 Jan 23;2008(1):CD004611. doi: 10.1002/14651858.CD004611.pub2.
Zotero 插件