Tzipori S, Chow C W, Powell H R
Department of Microbiology, Royal Children's Hospital, Melbourne, Australia.
J Clin Pathol. 1988 Oct;41(10):1099-103. doi: 10.1136/jcp.41.10.1099.
Escherichia coli O157:H7 was isolated from a fatal case of haemorrhagic colitis with haemolytic uraemic syndrome and neurological symptoms. This strain induced diarrhoea and neurological symptoms including incoordination, ataxia, and convulsions in piglets after oral inoculation. Similar neurological signs were seen in piglets inoculated intraperitoneally with bacterial extracts containing a shiga-like toxin that is elaborated by the bacteria. Histological examination of the brains from these piglets showed vascular damage and small infarcts confined to the cerebellum. Comparable lesions were also seen in the brain of the child from whom E coli O157:H7 was isolated. We suggest that the cerebral changes in the piglets and in the patient were caused by the shiga-like toxin elaborated by E coli O157:H7. The shiga-like toxin is thought to cause neurological abnormalities by damage to cerebral blood vessels rather than by a direct effect on the neurones.
从一例伴有溶血尿毒综合征和神经症状的出血性结肠炎致死病例中分离出了大肠杆菌O157:H7。该菌株经口服接种后可在仔猪中引发腹泻及包括共济失调、运动失调和惊厥在内的神经症状。在腹腔接种含该细菌产生的志贺样毒素的细菌提取物的仔猪中也观察到了类似的神经体征。对这些仔猪大脑的组织学检查显示血管损伤和局限于小脑的小梗死灶。在分离出大肠杆菌O157:H7的儿童大脑中也发现了类似病变。我们认为，仔猪和患者大脑的变化是由大肠杆菌O157:H7产生的志贺样毒素引起的。志贺样毒素被认为是通过损伤脑血管而非直接作用于神经元来导致神经异常的。
