Department of Biotechnology, University of Rijeka, Centre for High-Throughput Technologies, Radmile Matejcic 2, 51 000 Rijeka, Croatia.
Faculty of Medicine, Juraj Dobrila University of Pula, Zagrebacka 30, 52 100 Pula, Croatia.
Curr Med Chem. 2020;27(8):1367-1381. doi: 10.2174/0929867326666181220095343.
The metastatic process has still not been completely elucidated, probably due to insufficient knowledge of the underlying mechanisms. Here, we provide an overview of the current findings that shed light on specific molecular alterations associated with metastasis and present novel concepts in the treatment of the metastatic process. In particular, we discuss novel pharmacological approaches in the clinical setting that target metastatic progression. New insights into the process of metastasis allow optimisation and design of new treatment strategies, especially in view of the fact that metastatic cells share common features with stem cells. Nano- and micro-technologies are herein elaborated in details as a promising therapeutic concept in targeted drug delivery for metastatic cancer. Progression in the field could provide a more efficient way to tackle metastasis and thus bring about advancements in the treatment and management of patients with advanced cancer.
转移过程尚未完全阐明，这可能是由于对潜在机制的了解不足。在这里，我们提供了当前研究结果的概述，这些结果揭示了与转移相关的特定分子改变，并提出了转移过程治疗的新概念。特别是，我们讨论了临床环境中靶向转移进展的新的药理学方法。对转移过程的新认识允许优化和设计新的治疗策略，特别是考虑到转移细胞与干细胞具有共同的特征。本文详细阐述了纳米和微技术作为转移性癌症靶向药物输送的一种有前途的治疗概念。该领域的进展可以提供一种更有效的方法来解决转移问题，从而在治疗和管理晚期癌症患者方面取得进展。
