1Department of Clinical Laboratory, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
2Department of Laboratory Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang 330006, PR China.
J Med Microbiol. 2019 Feb;68(2):201-205. doi: 10.1099/jmm.0.000911. Epub 2018 Dec 20.
Between September 2013 and March 2016, 26 (1.95 %) of 1333 Staphylococcus aureus clinical isolates from a Chinese hospital were found to be resistant to mupirocin, including 18 (1.35 %) with high-level mupirocin resistance and 8 (0.6 %) with low-level mupirocin resistance. Among the 18 isolates with high-level mupirocin resistance, 17 were associated with plasmid-mediated mupA. Meanwhile, the 8 isolates with low-level mupirocin resistance were shown to have a V588F mutation in ileS. A total of 14 sequence types (STs) and 18 spa types were identified. All four isolates with t062 belonged to ST965. Three ST5-MRSA-SCCmec II were linked to t311, which was not previously reported. Furthermore, ST764-MRSA-SCCmec II-t002, exclusively found in Japan before, was identified in this study. In conclusion, we observed relatively low prevalence of mupirocin resistance among S. aureus with considerable heterogeneity in East China. Newly emerging MRSA clones with high-level mupirocin resistance should be of concern.
2013 年 9 月至 2016 年 3 月期间，从中国一家医院的 1333 株金黄色葡萄球菌临床分离株中发现 26 株（1.95%）对莫匹罗星耐药，其中 18 株（1.35%）为高水平莫匹罗星耐药，8 株（0.6%）为低水平莫匹罗星耐药。在 18 株高水平莫匹罗星耐药株中，17 株与质粒介导的 mupA 有关。同时，8 株低水平莫匹罗星耐药株的 ileS 有 V588F 突变。共鉴定出 14 种序列型（ST）和 18 种 spa 型。所有 4 株带有 t062 的分离株均属于 ST965。3 株 ST5-MRSA-SCCmec II 与之前未报道过的 t311 有关。此外，本研究还鉴定出了之前仅在日本发现的 ST764-MRSA-SCCmec II-t002。总之，我们观察到中国东部地区金黄色葡萄球菌对莫匹罗星的耐药率相对较低，但存在相当大的异质性。应关注新出现的高水平莫匹罗星耐药性的 MRSA 克隆。
