Reinberg Y, Gonzalez R, Fryd D, Mauer S M, Najarian J S
Department of Urologic Surgery, University of Minnesota Hospital and Clinic, Minneapolis.
J Urol. 1988 Dec;140(6):1491-3. doi: 10.1016/s0022-5347(17)42082-9.
The effect of vesical dysfunction on the survival and function of renal transplants was evaluated by a retrospective study in which 18 children with posterior urethral valves and 18 children with vesicoureteral reflux were randomly matched with 36 children used as controls. There was no statistically significant difference in patient survival among the 3 groups. Five years after transplantation 50 per cent of the grafts in children with posterior urethral valves were functioning, while 73 and 75 per cent, respectively, of the grafts were functioning in children with vesicoureteral reflux and in the control group. Renal function during the 5 years was significantly better in children in the control group and in those with vesicoureteral reflux than in children with posterior urethral valves. We believe that the presence of an abnormal bladder may alter graft survival and adversely affect the function of the transplanted kidney.
通过一项回顾性研究评估膀胱功能障碍对肾移植存活及功能的影响，该研究将18例后尿道瓣膜患儿和18例膀胱输尿管反流患儿与36例用作对照的患儿进行随机匹配。三组患者的生存率无统计学显著差异。移植后5年，后尿道瓣膜患儿中50%的移植物仍在发挥功能，而膀胱输尿管反流患儿和对照组中分别有73%和75%的移植物在发挥功能。在这5年期间，对照组患儿和膀胱输尿管反流患儿的肾功能明显优于后尿道瓣膜患儿。我们认为，异常膀胱的存在可能会改变移植物的存活，并对移植肾的功能产生不利影响。
