Chen Yong-Xing, Chen Qiong, Zhang Ying-Xian, Liu Fang, Yang Hai-Hua, Wu Sheng-Nan, Wei Hai-Yan
Department of Endocrinology and Inherited Metabolism, Children's Hospital Affiliated to Zhengzhou University/Henan Children's Hospital/Zhengzhou Children's Hospital, Zhengzhou 450000, China.
Zhongguo Dang Dai Er Ke Za Zhi. 2018 Dec;20(12):1020-1023. doi: 10.7499/j.issn.1008-8830.2018.12.008.
To study the protective effect of vitamin A on residual pancreatic β cell function in children with type 1 diabetes mellitus (T1DM) and its mechanism.
A total of 46 children with T1DM (with a course of disease of 0.5-1 year) were randomly divided into an intervention group and a non-intervention group (n=23 each). The children in both groups were given insulin treatment, and those in the intervention group were also given vitamin A at a daily dose of 1 500-2 000 IU. A total of 25 healthy children were enrolled as the control group. The daily dose of insulin was calculated for the children with T1DM, and the serum levels of glycosylated hemoglobin (HbA1C), stimulated C-peptide, vitamin A, and interleukin-17 (IL-17) were measured before intervention and 3 months after intervention.
Before vitamin A intervention, the intervention group and the non-intervention group had a significantly lower serum level of vitamin A and a significantly higher level of IL-17 than the control group (P<0.01). After 3 months of intervention, the intervention group had significantly lower serum IL-17 level and insulin dose and a significantly higher level of stimulated C-peptide than the non-intervention group (P<0.05).
Vitamin A may protect residual pancreatic β cell function, possibly by improving the abnormal secretion of IL-17 in children with T1DM.
研究维生素A对1型糖尿病（T1DM）患儿残余胰岛β细胞功能的保护作用及其机制。
46例病程0.5 - 1年的T1DM患儿随机分为干预组和非干预组，每组23例。两组患儿均给予胰岛素治疗，干预组患儿同时给予每日剂量为1500 - 2000 IU的维生素A。选取25例健康儿童作为对照组。计算T1DM患儿的胰岛素日剂量，并在干预前及干预3个月后检测糖化血红蛋白（HbA1C）、刺激后C肽、维生素A及白细胞介素-17（IL-17）的血清水平。
维生素A干预前，干预组和非干预组血清维生素A水平显著低于对照组，IL-17水平显著高于对照组（P<0.01）。干预3个月后，干预组血清IL-17水平、胰岛素剂量显著低于非干预组，刺激后C肽水平显著高于非干预组（P<0.05）。
维生素A可能通过改善T1DM患儿IL-17的异常分泌来保护残余胰岛β细胞功能。
