School of Public Health and Health Sciences, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Department of Traditional Chinese Medicine, Tianjin First Central Hospital, Tianjin, China.
Medicine (Baltimore). 2024 Oct 11;103(41):e40029. doi: 10.1097/MD.0000000000040029.
There is controversy about the relationship between type 1 diabetes and vitamin A (VA) levels in the body. Through meta-analysis, the results of related studies can be aggregated to more accurately estimate the relationship between type 1 diabetes mellitus (T1DM) patients and the level of VA in the body.
Our purpose is to review the study to investigate VA levels in type T1DM patients and to provide recommendations for future studies. Until January 2024, we searched the National Library of Medicine (PubMed), Cochrane Library, Embase Databases, Web of Sciences, Scopus, China National Knowledge Infrastructure (CNKI), VIP databases (VIP) and WAN FANG databases. After a systematic search, 8 case-control studies were included in our meta-analysis. In the process of data inclusion and extraction, the 2 reviewers selected literature independently of each other. In this study, RevMan5.3 software was used for meta-analysis.
Eight case-control studies involving 689 participants were screened. The results after meta-analysis showed that there was a significant difference in serum VA between the patients with T1DM and the control group (standardized mean difference [SMD] = -0.82, 95% CI [-1.29, -0.36], P < .001, random effects model) with significant heterogeneity among these studies (P < .001, I2 = 84%). Similarly, the difference in the high-performance liquid chromatography (HPLC) subgroup on serum VA (SMD = -0.99, 95% CI [-1.60, -0.38], P = .002) as well as the difference in the countries of Asia and Europe subgroup on serum VA (SMD = -0.60, 95% CI [-1.15, -0.05], P = .03; SMD = -1.06, 95% CI [-1.88, -0.24], P = .01) were suggested to be statistically significant. A significant result was also observed in the National Diabetes Data Group (NDDG) criteria subgroup (SMD = -0.48, 95% CI [-0.85, -0.12]).
Serum VA levels seem to have decreased in T1DM patients. Further research is needed to strengthen this finding and clarify possible impact mechanisms.
1 型糖尿病与体内维生素 A（VA）水平之间的关系存在争议。通过荟萃分析，可以汇总相关研究的结果，从而更准确地估计 1 型糖尿病（T1DM）患者与体内 VA 水平之间的关系。
我们的目的是综述研究 T1DM 患者体内 VA 水平，并为未来的研究提供建议。截至 2024 年 1 月，我们检索了美国国立医学图书馆（PubMed）、考科兰协作图书馆、Embase 数据库、Web of Sciences、Scopus、中国知网（CNKI）、维普数据库（VIP）和万方数据库。经过系统检索，共有 8 项病例对照研究纳入荟萃分析。在纳入和提取数据的过程中，两位审阅者独立选择文献。本研究采用 RevMan5.3 软件进行荟萃分析。
筛选出 8 项涉及 689 名参与者的病例对照研究。荟萃分析结果显示，T1DM 患者与对照组之间的血清 VA 水平存在显著差异（标准化均数差 [SMD] = -0.82，95%CI [-1.29，-0.36]，P <.001，随机效应模型），且这些研究之间存在显著异质性（P <.001，I2 = 84%）。同样，基于高效液相色谱（HPLC）的血清 VA 亚组（SMD = -0.99，95%CI [-1.60，-0.38]，P =.002）和基于亚洲和欧洲国家的血清 VA 亚组（SMD = -0.60，95%CI [-1.15，-0.05]，P =.03；SMD = -1.06，95%CI [-1.88，-0.24]，P =.01）的差异也具有统计学意义。在国家糖尿病数据组（NDDG）标准亚组（SMD = -0.48，95%CI [-0.85，-0.12]）也观察到显著结果。
血清 VA 水平似乎在 T1DM 患者中降低。需要进一步研究来加强这一发现并阐明可能的影响机制。
