Narendran Parth, Solomon Thomas P, Kennedy Amy, Chimen Myriam, Andrews Rob C
The Institute of Biomedical Research, School of Clinical and Experimental Medicine, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK,
Diabetologia. 2015 Jan;58(1):10-8. doi: 10.1007/s00125-014-3412-8. Epub 2014 Nov 4.
Type 1 diabetes is characterised by immune-mediated destruction of insulin-producing beta cells. Significant beta cell function is usually present at the time of diagnosis with type 1 diabetes, and preservation of this function has important clinical benefits. The last 30 years have seen a number of largely unsuccessful trials for beta cell preservation, some of which have been of therapies that have potential for significant harm. There is a need to explore new, more tolerable approaches to preserving beta cell function that can be implemented on a large clinical scale. Here we review the evidence for physical exercise as a therapy for the preservation of beta cell function in patients with newly diagnosed type 1 diabetes. We highlight possible mechanisms by which exercise could preserve beta cell function and then present evidence from other models of diabetes that demonstrate that exercise preserves beta cell function. We conclude by proposing that there is now a need for studies to explore whether exercise can preserve beta cell in patients newly diagnosed with type 1 diabetes.
1型糖尿病的特征是胰岛素分泌β细胞受到免疫介导的破坏。在1型糖尿病诊断时，通常存在显著的β细胞功能，保留这种功能具有重要的临床益处。在过去30年里，有许多关于β细胞保留的试验大多未成功，其中一些疗法可能有重大危害。需要探索新的、更可耐受的方法来保留β细胞功能，以便能够在大规模临床中实施。在此，我们综述了体育锻炼作为一种治疗新诊断1型糖尿病患者β细胞功能保留疗法的证据。我们强调了运动可能保留β细胞功能的潜在机制，然后展示了来自其他糖尿病模型的证据，这些证据表明运动可保留β细胞功能。我们最后提议，现在需要进行研究，以探索运动是否能保留新诊断1型糖尿病患者的β细胞功能。
