Department of Chemistry, Northeast Normal University, Changchun 130024, PR China.
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
Mater Sci Eng C Mater Biol Appl. 2019 Feb 1;95:256-263. doi: 10.1016/j.msec.2018.10.072. Epub 2018 Oct 22.
Graphene-based nanomaterials show great potential in photo-chemotherapy, but their photo-thermal effect is not very satisfactory. Herein, we presented a facile and low-cost strategy to grow Au clusters on the reduced graphene oxide (rGO) sheets aiming to improve photothermal effect. Au clusters with low-concentration was directly conjugated on the surface of rGO by electrostatic forces. To improve its biocompatibility, 3‑(3‑phenylureido) propanoic acid (PPA)-PEG (PPEG) had been introduced as biodegradable backbone to form rGO/Au/PPEG nanohybrids via π-π accumulation. The obtained rGO-based nanohybrids showed excellent biocompatibility, stability, low cytotoxicity, and enhanced photo-thermal conversion efficiency. To verify the synergistic photo-chemotherapy, doxorubicin (DOX) as a drug model had been loaded in rGO/Au/PPEG nanohybrids. The results indicated that rGO/Au/PPEG/DOX exhibited synergistic therapeutic efficacy compared with single chemotherapy or photothermal therapy, endowing this designed rGO-based nanohybrids with great potential for cancer treatments.
基于石墨烯的纳米材料在光化疗中显示出巨大的潜力，但它们的光热效应并不十分理想。在此，我们提出了一种简便、低成本的策略，即在还原氧化石墨烯（rGO）片上生长金纳米簇，以提高光热效应。通过静电力将低浓度的金纳米簇直接共轭在 rGO 表面。为了提高其生物相容性，将 3-（3-苯脲基）丙酸（PPA）-PEG（PPEG）作为可生物降解的主链，通过π-π堆积形成 rGO/Au/PPEG 纳米杂化物。所得到的基于 rGO 的纳米杂化物表现出优异的生物相容性、稳定性、低细胞毒性和增强的光热转换效率。为了验证协同光化疗，将阿霉素（DOX）作为药物模型载入 rGO/Au/PPEG 纳米杂化物中。结果表明，与单一化疗或光热治疗相比，rGO/Au/PPEG/DOX 表现出协同治疗效果，使这种设计的基于 rGO 的纳米杂化物在癌症治疗方面具有巨大的潜力。
