Kumar Arun, Sharipov Mirkomil, Turaev Abbaskhan, Azizov Shavkatjon, Azizov Ismatdjan, Makhado Edwin, Rahdar Abbas, Kumar Deepak, Pandey Sadanand
Department of Pharmaceutical Chemistry, School of Pharmaceutical Sciences, Shoolini University, Solan 173229, India.
Department of Chemistry, Changwon National University, Changwon 51140, Korea.
Polymers (Basel). 2022 Jul 26;14(15):3027. doi: 10.3390/polym14153027.
Globally, cancer is affecting societies and is becoming an important cause of death. Chemotherapy can be highly effective, but it is associated with certain problems, such as undesired targeting and multidrug resistance. The other advanced therapies, such as gene therapy and peptide therapy, do not prove to be effective without a proper delivery medium. Polymer-based hybrid nanoarchitectures have enormous potential in drug delivery. The polymers used in these nanohybrids (NHs)provide them with their distinct properties and also enable the controlled release of the drugs. This review features the recent use of polymers in the preparation of different nanohybrids for cancer therapy published since 2015 in some reputed journals. The polymeric nanohybrids provide an advantage in drug delivery with the controlled and targeted delivery of a payload and the irradiation of cancer by chemotherapeutical and photodynamic therapy.
在全球范围内，癌症正在影响各个社会，并日益成为一个重要的死亡原因。化疗可能非常有效，但它也伴随着某些问题，如靶向不理想和多药耐药性。其他先进疗法，如基因疗法和肽疗法，如果没有合适的递送介质，也无法证明是有效的。基于聚合物的杂化纳米结构在药物递送方面具有巨大潜力。这些纳米杂化物（NHs）中使用的聚合物赋予它们独特的性质，还能实现药物的控释。这篇综述重点介绍了自2015年以来在一些著名期刊上发表的关于聚合物在制备用于癌症治疗的不同纳米杂化物中的最新应用。聚合物纳米杂化物在药物递送方面具有优势，能够实现有效载荷的可控靶向递送，并通过化疗和光动力疗法对癌症进行照射。
