Department of Infectious Diseases, the First Affiliated Hospital of Wenzhou Medical University, Hepatology Institute of Wenzhou Medical University, Wenzhou Key Laboratory of Hepatology, Wenzhou, Zhejiang, China.
Department of Infectious Diseases, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.
Clin Nutr. 2019 Dec;38(6):2552-2557. doi: 10.1016/j.clnu.2018.11.030. Epub 2018 Dec 4.
Nonalcoholic fatty liver disease (NAFLD) is the most predominant chronic liver disease worldwide. Effect of coffee on NAFLD risk and its potential dose-response patterns were explored in the study.
PubMed, Web of Science, MEDLINE, Cochrane and Embase were searched up to 10 April 2018. We performed pair-wise meta-analysis of <1 cup per day vs. 1-2 cups per days or >2 cups per day to pool the relative risks (RRs) and corresponding 95% confidence intervals (CIs). And dose-response analysis was used to estimate relationship of NAFLD occurrence with coffee intake.
Seven articles were included with 4825 cases and 49,616 non-cases. Compared with <1 cup, 1-2 cups or >2 cups of coffee consumption per day were not significantly associated with NAFLD occurrence, and RR were 0.97 (95% CI: 0.85-1.11) and 0.88 (95%CI: 0.72-1.06). However, the summary RR of the highest versus lowest coffee consumption was 0.94 (95% CI: 0.92-0.97). Dose-response meta-analysis presented a non-linearity curve relationship of coffee and NAFLD occurrence while coffee consumption >3 cups per day reduced NAFLD significantly.
Coffee intake level more than 3 cups was observed lower risk of NAFLD than <2 cups per day. Although the risk of NAFLD was inversely associated with coffee consumption, while relevance may not be very close and more observational studies would be needed to verify the relationship of coffee and NAFLD.
非酒精性脂肪性肝病（NAFLD）是全球最常见的慢性肝病。本研究旨在探讨咖啡对 NAFLD 风险的影响及其潜在的剂量反应模式。
检索了 PubMed、Web of Science、MEDLINE、Cochrane 和 Embase 数据库，截至 2018 年 4 月 10 日。我们对每天饮用<1 杯与 1-2 杯或>2 杯咖啡进行了两两荟萃分析，以汇总相对风险（RR）及其相应的 95%置信区间（CI）。并进行了剂量-反应分析，以评估咖啡摄入与 NAFLD 发生之间的关系。
共纳入 7 项研究，包含 4825 例病例和 49616 例非病例。与每天饮用<1 杯相比，每天饮用 1-2 杯或>2 杯咖啡与 NAFLD 发生无显著相关性，RR 分别为 0.97（95%CI：0.85-1.11）和 0.88（95%CI：0.72-1.06）。然而，最高与最低咖啡摄入量的汇总 RR 为 0.94（95%CI：0.92-0.97）。剂量-反应荟萃分析显示咖啡与 NAFLD 发生之间呈非线性曲线关系，而每天饮用咖啡>3 杯可显著降低 NAFLD 的发生风险。
与每天饮用<2 杯相比，每天饮用>3 杯咖啡可降低 NAFLD 的发病风险。尽管咖啡摄入量与 NAFLD 呈负相关，但相关性可能不太密切，需要更多的观察性研究来验证咖啡与 NAFLD 的关系。
