在酸性条件下，对乙酰氨基酚经亚硝酸盐处理形成重氮醌型诱变剂。

Formation of a diazoquinone-type mutagen from acetaminophen treated with nitrite under acidic conditions.

作者信息

Ohta T, Oribe H, Kameyama T, Goto Y, Takitani S

机构信息

Faculty of Pharmaceutical Sciences, Science University of Tokyo, Japan.

出版信息

Mutat Res. 1988 Nov-Dec;209(3-4):95-8. doi: 10.1016/0165-7992(88)90024-3.

DOI:10.1016/0165-7992(88)90024-3

PMID:3057376

Abstract

Acetaminophen (paracetamol) showed mutagenicity to Salmonella typhimurium TA100 and TA98 either with or without S9 mix when treated with excess nitrite in acidic solution. The mutagen was isolated and identified as 4-acetylamino-6-diazo-2,4-cyclohexadienone. Mutation tests and product analysis by high-performance liquid chromatography, however, suggested that this type of mutagen was hardly formed in the digestive tract of normal subjects.

摘要

在酸性溶液中用过量亚硝酸盐处理时，对乙酰氨基酚（扑热息痛）无论有无S9混合液存在，对鼠伤寒沙门氏菌TA100和TA98均表现出致突变性。诱变剂被分离并鉴定为4-乙酰氨基-6-重氮-2,4-环己二烯酮。然而，通过高效液相色谱法进行的突变试验和产物分析表明，在正常受试者的消化道中几乎不会形成这种类型的诱变剂。