Kondrashov A S
Research Computer Center, Pushchino, Moscow Region, USSR.
Nature. 1988 Dec 1;336(6198):435-40. doi: 10.1038/336435a0.
The origin and maintenance of sexual reproduction continues to be an important problem in evolutionary biology. If the deleterious mutation rate per genome per generation is greater than 1, then the greater efficiency of selection against these mutations in sexual populations may be responsible for the evolution of sex and related phenomena. In modern human populations detrimental mutations with small individual effects are probably accumulating faster than they are being eliminated by selection.
有性生殖的起源与维持仍是进化生物学中的一个重要问题。如果每代每个基因组的有害突变率大于1，那么有性群体中针对这些突变的选择效率更高，这可能是性别及相关现象进化的原因。在现代人群中，个体影响较小的有害突变积累的速度可能比通过选择将其消除的速度更快。
