糖化血红蛋白（HbA）检测的标准化
Standardization of the HbA Assay.
作者信息
Paleari Renata, Mosca Andrea
机构信息
Department of Physiopathology and Transplantation, Center for Metrological Traceability in Laboratory Medicine (CIRME), University of Milano, Italy.
出版信息
EJIFCC. 2018 Dec 5;29(4):298-302. eCollection 2018 Dec.
BACKGROUND
A project for the standardization of HbA was launched by the IFCC back in 2004.
MATERIALS AND METHODS
In this work we report on the state-of-the-art of the project on standardization of HbA. Data obtained from various EQAS studies, and from previous experimental evaluations, are presented.
RESULTS
We have proven that biases between various commercial methods are still currently significant. We have also shown that calibration by commutable control materials may halve the inter-method variability.
CONCLUSIONS
The foundation of the reference system for HbA, together with a brief preliminary presentation of the proposed primary reference measurement procedure based on ID-MS are outlined.
背景
国际临床化学和检验医学联合会（IFCC）早在2004年就启动了一项血红蛋白A（HbA）标准化项目。
材料与方法
在本研究中，我们报告了HbA标准化项目的最新进展。展示了从各种外部质量评估（EQAS）研究以及先前实验评估中获得的数据。
结果
我们已经证明，目前各种商业方法之间的偏差仍然很大。我们还表明，使用可互换的对照材料进行校准可使方法间的变异性减半。
结论
概述了HbA参考系统的基础，以及基于同位素稀释质谱法（ID-MS）的拟议主要参考测量程序的简要初步介绍。
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