Rohdewald P, Granitzki H W, Neddermann E
Institute for Pharmaceutical Chemistry, Wilhelms University of Münster, FRG.
Pharmacology. 1988;37(4):209-17. doi: 10.1159/000138468.
The analgesic efficacy of 50 and 100 mg tramadol and 500 and 1,000 mg metamizole was compared using a randomized double-blind design on 10 volunteers; drugs were given orally as solutions. Constant painful stimuli were applied by controlled electrical stimulation of tooth pulp. Analgesia was monitored by verbal pain rating, by measurement of the current necessary to evoke sensation in a tooth and with the aid of the amplitude of somatosensory evoked potential. All 3 algesimetric methods showed in complete agreement higher analgesia by the 100-mg dose of tramadol compared to all other medications; 50 mg tramadol and 1,000 mg metamizole were equipotent analgesic doses. The mean relative potencies of metamizole and tramadol were found to be 1:23 in agreement with clinical studies. Pain relief was limited to 3-4 h for 100 mg tramadol; 500 and 1,000 mg metamizole and 50 mg tramadol had a shorter period of analgesia.
采用随机双盲设计，对10名志愿者比较了50毫克和100毫克曲马多以及500毫克和1000毫克安乃近的镇痛效果；药物以溶液形式口服给药。通过对牙髓进行可控电刺激施加持续的疼痛刺激。通过言语疼痛评分、测量引起牙齿感觉所需的电流以及借助体感诱发电位的幅度来监测镇痛效果。所有三种痛觉测定方法均完全一致地显示，与所有其他药物相比，100毫克剂量的曲马多镇痛效果更佳；50毫克曲马多和1000毫克安乃近的镇痛剂量相当。发现安乃近和曲马多的平均相对效价为1:23，与临床研究结果一致。100毫克曲马多的止痛效果持续3 - 4小时；500毫克和1000毫克安乃近以及50毫克曲马多的镇痛时间较短。
