Jeyaraman Naveen, Migliorini Filippo, Murugan Shrideavi, Ramasubramanian Swaminathan, Balaji Sangeetha, Maffulli Nicola, Jeyaraman Madhan
Department of Orthopaedics, ACS Medical College and Hospital, Dr MGR Educational and Research Institute, Chennai 600077, Tamil Nadu, India.
Department of Orthopaedic and Trauma Surgery, Academic Hospital of Bolzano (SABES-ASDAA), 39100 Bolzano, Italy.
J Clin Med. 2024 Aug 14;13(16):4794. doi: 10.3390/jcm13164794.
Metamizole, or dipyrone, has been used for decades as a non-narcotic analgesic, providing pain relief from musculoskeletal disorders and antipyretic and antispasmolytic properties. Despite being in use since the 1920s, its mechanism of action still needs to be discovered. Despite causing fewer adverse effects when compared to other analgesics, its harmful effects on the blood and lack of evidence regarding its teratogenicity make the usage of the drug questionable, which has led to it being removed from the drug market of various countries. This narrative review aims to provide a detailed insight into the mechanism of action and efficacy, comparing its effectiveness and safety with other classes of drugs and the safety profile of metamizole.
安乃近，又称双氯芬酸钠，数十年来一直用作非麻醉性镇痛药，可缓解肌肉骨骼疾病引起的疼痛，并具有解热和解痉作用。尽管自20世纪20年代以来一直在使用，但仍需探索其作用机制。与其他镇痛药相比，它引起的不良反应较少，但其对血液的有害影响以及缺乏关于其致畸性的证据，使得该药物的使用存在疑问，这导致它在各国药品市场上被下架。本叙述性综述旨在深入详细地了解其作用机制和疗效，将其有效性和安全性与其他类药物进行比较，并探讨安乃近的安全性概况。
