Natarajan K, Wernli B, Franklin R M
Department of Structure Biology, University of Basel, Switzerland.
Trop Med Parasitol. 1988 Sep;39(3):203-7.
Serum pools from mice undergoing lethal infection with Plasmodium berghei inhibit the growth of an IL2-dependent mouse cytotoxic T cell line (CTLL). A partially purified preparation of the inhibitory factor specifically inhibited IL2-mediated events such as IL2-dependent CTLL growth and the Con A mitogenic response of normal mouse spleen cells. Production of and response to IL1, as well as growth of myeloma lines, was not affected. Administration of the partially purified preparation to normal mice resulted in a significant depression in IL2 production, thereby indicating a role for the inhibitory factor in maintaining immune depression in malaria-infected mice.
感染致死剂量伯氏疟原虫的小鼠血清池可抑制白细胞介素2（IL2）依赖的小鼠细胞毒性T细胞系（CTLL）的生长。抑制因子的部分纯化制剂可特异性抑制IL2介导的事件，如IL2依赖的CTLL生长以及正常小鼠脾细胞的刀豆蛋白A促有丝分裂反应。IL1的产生和反应以及骨髓瘤细胞系的生长均未受影响。将部分纯化制剂给予正常小鼠会导致IL2产生显著降低，从而表明抑制因子在维持疟疾感染小鼠的免疫抑制中起作用。
