Bender Jeffrey M, Li Fan, Martelly Shoria, Byrt Erin, Rouzier Vanessa, Leo Marguerite, Tobin Nicole, Pannaraj Pia S, Adisetiyo Helty, Rollie Adrienne, Santiskulvong Chintda, Wang Shaun, Autran Chloe, Bode Lars, Fitzgerald Daniel, Kuhn Louise, Aldrovandi Grace M
Children's Hospital Los Angeles, Los Angeles, CA 90027, USA. Department of Pediatrics, University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA.
Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
Sci Transl Med. 2016 Jul 27;8(349):349ra100. doi: 10.1126/scitranslmed.aaf5103.
More than 1 million HIV-exposed, uninfected infants are born annually to HIV-positive mothers worldwide. This growing population of infants experiences twice the mortality of HIV-unexposed infants. We found that although there were very few differences seen in the microbiomes of mothers with and without HIV infection, maternal HIV infection was associated with changes in the microbiome of HIV-exposed, uninfected infants. Furthermore, we observed that human breast milk oligosaccharides were associated with bacterial species in the infant microbiome. The disruption of the infant's microbiome associated with maternal HIV infection may contribute to the increased morbidity and mortality of HIV-exposed, uninfected infants.
全球每年有超过100万感染HIV但未受感染的婴儿出生于HIV阳性母亲。这一不断增长的婴儿群体的死亡率是未接触HIV婴儿的两倍。我们发现，尽管感染HIV和未感染HIV的母亲的微生物群差异极小，但母亲感染HIV与感染HIV但未受感染婴儿的微生物群变化有关。此外，我们观察到人类母乳中的低聚糖与婴儿微生物群中的细菌种类有关。与母亲感染HIV相关的婴儿微生物群破坏可能导致感染HIV但未受感染婴儿的发病率和死亡率增加。
