Laboratoire de psychophysiologie cognitive et sociale, Montreal, Qc, Canada; Centre de recherche de l'Institut universitaire en santé mentale de Montréal, Montreal, Qc, Canada; Département de neurosciences, Université de Montréal, Montreal, Qc, Canada.
Laboratoire de psychophysiologie cognitive et sociale, Montreal, Qc, Canada; Centre de recherche de l'Institut universitaire en santé mentale de Montréal, Montreal, Qc, Canada; Département de neurosciences, Université de Montréal, Montreal, Qc, Canada; Département de psychiatrie, Université de Montréal, Montreal, Qc, Canada.
Clin Neurophysiol. 2019 Jun;130(6):1041-1057. doi: 10.1016/j.clinph.2018.10.022. Epub 2018 Dec 7.
Tourette syndrome (TS) patients face various cognitive and motor impairments. Event-related potentials (ERP) constitute an effective way to investigate the neural correlates of those functional impairments. Various components have been assessed among TS patients, with a wide variety of paradigms. This systematic review aimed to evaluate the portrait of ERP components in TS patients, and to understand the factors leading to discrepancies across studies.
A literature search was performed in Embase, PsycINFO, Pubmed, and Web of Science, to identify studies that conducted ERP experiments among TS patients. Of the 372 unique records identified, 47 met inclusion criteria and were included in our systematic review.
Various ERP particularities were reported among included studies. Many discrepancies exist, but impairments in motor-related potentials and contingent negative variation seem constant across studies. Divergent findings point toward a possibly reduced P3b during oddball tasks.
ERPs offer an insightful investigation into the cognitive and motor functions of TS patients. Future studies should always control for confounding factors such as comorbidity, age, or medication status.
This is the first systematic review of ERP in TS patients. Motor-related and slow cortical potentials could constitute electrophysiological markers of TS.
妥瑞氏综合征（TS）患者面临各种认知和运动障碍。事件相关电位（ERP）是研究这些功能障碍神经相关性的有效方法。已经在 TS 患者中评估了各种成分，采用了各种各样的范式。本系统评价旨在评估 TS 患者 ERP 成分的特征，并了解导致研究间差异的因素。
在 Embase、PsycINFO、Pubmed 和 Web of Science 中进行文献检索，以确定在 TS 患者中进行 ERP 实验的研究。在 372 条独特记录中，有 47 条符合纳入标准并包含在我们的系统评价中。
纳入的研究报告了各种 ERP 的特点。存在许多差异，但运动相关电位和条件负变似乎在研究中是一致的。不同的发现表明在奇偶任务中 P3b 可能减少。
ERP 为妥瑞氏综合征患者的认知和运动功能提供了深入的研究。未来的研究应始终控制混杂因素，如合并症、年龄或药物状态。
这是 TS 患者 ERP 的首次系统评价。运动相关和慢皮质电位可能构成 TS 的电生理标志物。
