Department of Gastroenterology, Xi'an Central Hospital, Xi'an 710003, Shaanxi, China.
Department of Radiotherapy, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China.
Int J Biol Macromol. 2019 Apr 1;126:318-325. doi: 10.1016/j.ijbiomac.2018.12.105. Epub 2018 Dec 20.
Lysine demethylase 3A (KDM3A) is been suggested to accelerate tumor cell migration and invasion in breast cancer, cervical cancer, Ewing sarcoma and neuroblastoma. The role of KDM3A in colorectal cancer progression and metastasis remains unknown. The aim of this study is to explore the clinical significance and biological function of KDM3A in colorectal cancer. In our results, we found KDM3A expression was significantly increased in colorectal cancer metastatic lesions compared with primary lesions, but had no statistical difference between colorectal cancer tissues and normal colorectal tissues. Moreover, high KDM3A expression was correlated with poor histological differentiation, and advanced clinical stage, N classification, M classification and short overall survival in colorectal cancer patients. Univariate and multivariate Cox proportional hazards regression analyses indicated that high expression of KDM3A served as an independent unfavorable prognostic factor in colorectal cancer patients. The loss-of-function and gain-of-function studies showed KDM3A functioned as oncogene to regulate colorectal cancer cell migration and invasion through modulating EMT and MMPs. In conclusion, KDM3A is a promising therapeutic target for preventing metastasis and improving prognosis in colorectal cancer.
赖氨酸去甲基酶 3A（KDM3A）被认为可以加速乳腺癌、宫颈癌、尤文肉瘤和神经母细胞瘤中的肿瘤细胞迁移和侵袭。KDM3A 在结直肠癌进展和转移中的作用尚不清楚。本研究旨在探讨 KDM3A 在结直肠癌中的临床意义和生物学功能。在我们的研究结果中，我们发现 KDM3A 在结直肠癌转移病灶中的表达明显高于原发性病灶，但在结直肠癌组织和正常结直肠组织之间没有统计学差异。此外，高 KDM3A 表达与结直肠癌患者的组织学分化差、临床分期较晚、N 分级、M 分级和总生存期较短相关。单因素和多因素 Cox 比例风险回归分析表明，KDM3A 高表达是结直肠癌患者的独立不良预后因素。功能丧失和功能获得研究表明，KDM3A 通过调节 EMT 和 MMPs 发挥癌基因作用，调节结直肠癌细胞的迁移和侵袭。总之，KDM3A 是预防结直肠癌转移和改善预后的有前途的治疗靶点。
