Student Research Committee, Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran.
Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, I.R. Iran.
J Ren Nutr. 2019 Jul;29(4):343-349. doi: 10.1053/j.jrn.2018.10.007. Epub 2018 Dec 19.
The aim of this article was to assess the association between low-carbohydrate high-protein (LCHP) diet score and the risk of incident chronic kidney disease (CKD).
This cohort study was conducted on 1,797 Iranian participants, aged ≥20 years, followed-up for a mean of 6.1 years. Using a valid and reliable food-frequency questionnaire at baseline, LCHP diet score between 0 and 12 points were determined. Anthropometric measures and biochemical indicators were assessed. Participants were classified based on their estimated glomerular filtration rate (eGFR) levels using the National Kidney Foundation guidelines; eGFR ≥ 60 mL/minute/1.73 m as not having CKD and eGFR < 60 mL/minute/1.73 m as having CKD. Multivariable logistic regression was used to estimate the odds ratio for the occurrence of CKD according to the tertiles of LCHP diet score.
Mean (standard) age of participants (48% male) was 37.7 (12.2) years at baseline. The median (25-75 interquartile range) of LCHP diet for all subjects was 7 (4-8), and incidence of CKD was 14.1%. After adjusting for age, sex, smoking status, physical activity, total calorie intake, body mass index, diabetes, hypertension, and baseline eGFR, participants in the highest tertile of LCHP diet had greater risk of incident CKD (odds ratio: 1.48; 95% confidence interval: 1.03-2.15), in comparison to those in the lowest one (P for trend = .027).
Our findings demonstrate the hypothesis that higher score of LCHP diet may have adverse effects on incidence and development of CKD.
本文旨在评估低碳水化合物高蛋白(LCHP)饮食评分与慢性肾脏病(CKD)发病风险之间的关系。
本队列研究纳入了 1797 名年龄≥20 岁的伊朗参与者,平均随访 6.1 年。在基线时使用有效且可靠的食物频率问卷,确定 LCHP 饮食评分在 0 至 12 分之间。评估人体测量指标和生化指标。根据美国国家肾脏病基金会(National Kidney Foundation)指南,根据估计肾小球滤过率(eGFR)水平将参与者分类;eGFR≥60 mL/min/1.73 m 为无 CKD,eGFR<60 mL/min/1.73 m 为 CKD。使用多变量逻辑回归估计根据 LCHP 饮食评分三分位数发生 CKD 的比值比。
参与者的平均(标准)年龄(48%为男性)为 37.7(12.2)岁。所有受试者的 LCHP 饮食中位数(25-75 分位距)为 7(4-8),CKD 的发病率为 14.1%。在校正年龄、性别、吸烟状况、身体活动、总热量摄入、体重指数、糖尿病、高血压和基线 eGFR 后,LCHP 饮食评分最高三分位的参与者发生 CKD 的风险更高(比值比:1.48;95%置信区间:1.03-2.15),与最低三分位的参与者相比(趋势 P 值=0.027)。
我们的研究结果表明,较高的 LCHP 饮食评分可能对 CKD 的发生和发展产生不利影响。