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代谢组学分析及 和 (菊科)的抗感染潜力。

Metabolomic profiling and anti-infective potential of and (Family Asteraceae).

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Minia University, Minia, Egypt.

Department of Botany II, Julius-von-Sachs Institute for Biological Sciences, University of Würzburg, Würzburg, Germany.

出版信息

Nat Prod Res. 2020 Sep;34(18):2612-2615. doi: 10.1080/14786419.2018.1544975. Epub 2018 Dec 22.

Abstract

The present study evaluates the chemical composition of and based on their metabolomic profiles using liquid chromatography coupled with high-resolution mass spectrometry (LC-HR-MS), alongside with the anti-infective activities of their ethanol extracts, as well as, different fractions. A significant difference was observed between the LC-MS profiles of the two plants such as, coumarins, sesquiterpene lactones and phenylethanoids which were characteristic for , while amides and phenolic acid derivatives were characteristic for . These results highlight the chemical potential of and Furthermore, the ethyl acetate fraction of showed a significant antimalarial activity with IC values of 21.03 and 13.72 µg/mL against and , respectively.

摘要

本研究基于代谢组学图谱,采用液相色谱-高分辨质谱联用(LC-HR-MS)技术,评估了 和 的化学成分,并对其乙醇提取物及不同馏分的抗感染活性进行了研究。结果表明,两种植物的 LC-MS 图谱存在显著差异,如香豆素、倍半萜内酯和苯乙醇苷类化合物是 的特征成分,而酰胺类和酚酸衍生物是 的特征成分。这些结果突出了 和 的化学潜力。此外, 的乙酸乙酯馏分对 和 均表现出显著的抗疟活性,IC 值分别为 21.03 和 13.72 μg/mL。

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