Laboratory of Natural Product Chemistry, Department of Pharmaceutical Sciences and Natural Products, School of Basic and Applied Sciences, Central University of Punjab, Bathinda, India.
Nat Prod Res. 2020 Jun;34(11):1571-1574. doi: 10.1080/14786419.2018.1517123. Epub 2018 Dec 22.
Breast cancer is a disease where cells in the tissue of the breast, grow and divide without normal control. Breast cancer is second major cause for death in world wide. Importance of natural product increase due to adverse effect of existing synthetic drugs. comprises phytoestrogens which can be used for the treatment of breast cancer. In the current study, antiproliferative activity of the extracts of is performed in T47D cancer cell lines. Outcomes of the result indicated that aqueous methanol and methanol extract showed excellent antiproliferative activity as compared to bazedoxifene (standard), ethyl acetate and petroleum ether extract study of reported phytochemical constituents of was performed for understand the molecular mechanism and prospect pharmacophore development. Furthermore, compound (rutin) which has been earlier reported and isolated from alcoholic extract exhibited the remarkable binding profile with estrogen receptor α. For that reason, our study proposed that could be used as a new source for the treatment of breast cancer.
乳腺癌是一种组织细胞在乳房中无正常控制地生长和分裂的疾病。乳腺癌是世界范围内第二大死亡原因。由于现有合成药物的副作用，天然产物的重要性增加。包含植物雌激素，可用于治疗乳腺癌。在目前的研究中，对 的提取物在 T47D 癌细胞系中的抗增殖活性进行了研究。结果表明，与 bazedoxifene（标准）相比，水甲醇和甲醇提取物表现出优异的抗增殖活性，乙酸乙酯和石油醚提取物研究报道了 的植物化学成分，以了解分子机制和展望药效基团的发展。此外，先前已报道并从醇提物中分离得到的化合物 （芦丁）与雌激素受体 α 表现出显著的结合特征。因此，我们的研究表明 可作为治疗乳腺癌的新来源。
