Arora Neelima, Banerjee Amit Kumar
Department of Biotechnology, Institute of Science, Jawaharlal Nehru Technological University-Hyderabad, Kukatpally, Hyderabad -500085, Telangana State, India.
Bioinformation. 2024 Jul 31;20(7):775-780. doi: 10.6026/973206300200775. eCollection 2024.
Shatavari () has been used for female health problems since ancient times and is useful for treating various female reproductive problems including menopausal problems, hormonal imbalance, lactation, menstrual issues, and others. Shatavarins, the primary phytoconstituents of Shatavari, have high molecular weights and may interact with hormone receptors. We have conducted a molecular docking analysis for different Shatavarins such as Shatavarin I, Shatavarin IV, Shatavarin VI, Shatavarin VII, Shatavarin VIII, Shatavarin IX, and Shatavarin X with different hormonal receptors such as estrogen alpha, beta, and gamma receptor, progesterone receptor, FSH, and LH receptors. The best docking conformations with the highest docking scores, specific interactions and bond formations, and the most important residues of the receptors were identified and reported. The study was successful in providing an initial comparative insight into the binding efficiencies of the Shatavarins for different female hormonal receptors.
自古代以来，印度白星海芋（Shatavari）就被用于解决女性健康问题，对治疗各种女性生殖问题有用，包括更年期问题、激素失衡、泌乳、月经问题等。印度白星海芋素（Shatavarins）是印度白星海芋的主要植物成分，分子量高，可能与激素受体相互作用。我们对不同的印度白星海芋素，如印度白星海芋素I、IV、VI、VII、VIII、IX和X，与不同的激素受体，如雌激素α、β和γ受体、孕激素受体、促卵泡激素（FSH）和促黄体生成素（LH）受体进行了分子对接分析。确定并报告了具有最高对接分数、特定相互作用和键形成以及受体最重要残基的最佳对接构象。该研究成功地初步比较了印度白星海芋素对不同女性激素受体的结合效率。
