Florholmen J, Lindal S, Røkke O, Olsen R, Burhol P G, Revhaug A
Dept. of Medicine, University Hospital of Tromsø, Norway.
APMIS. 1988 Nov;96(11):991-6. doi: 10.1111/j.1699-0463.1988.tb00972.x.
Intravenous administration of Escherichia coli endotoxin caused a state of shock with increased serum cationic trypsin-like immunoreactivity (CTLI) in a porcine model. The pancreatic acinar cells revealed focal changes, including intracellular oedema, appearance of membrane-bound vacuoles and breaks in the plasma membrane. In the micro circulatory vessels, there was swelling of endothelial cells. Similar changes have been observed in hemorrhagic and cardiogenic shock. This study demonstrates severe ultrastructural changes in the pancreas during E. coli endotoxin shock.
在猪模型中，静脉注射大肠杆菌内毒素可导致休克状态，血清阳离子胰蛋白酶样免疫反应性（CTLI）增加。胰腺腺泡细胞出现局灶性变化，包括细胞内水肿、膜结合空泡的出现以及质膜破裂。在微循环血管中，内皮细胞肿胀。在出血性休克和心源性休克中也观察到了类似的变化。本研究表明，在大肠杆菌内毒素休克期间，胰腺会出现严重的超微结构变化。
