Bende S, Bertók L, Bende S
Department of General and Thoracic Surgery, Semmelweis Teaching Hospital, Miskolc, Hungary.
Acta Chir Hung. 1992;33(1-2):197-208.
The ultrastructural changes of pancreas exocrine cells were studied after the intravenous administration of endotoxin (LPS) or radio-detoxified endotoxin (150 kGy 60Co-gamma irradiated: RD-LPS or Tolerin). The LPS (1 mg/rat) induces an autolytic destruction in the membranes of the mitochondria of the pancreas exocrine cells. The RD-LPS given in similar dose does not produce any autolytic change. However, a small dose (100/micrograms/rat) of RD-LPS (Tolerin) as a pretreatment can protect the autolytic destruction of the mitochondria induced by LPS. This may be attributed to the membrane stabilizing effect of RD-LPS.
静脉注射内毒素（LPS）或经辐射解毒的内毒素（150 kGy 60Co-γ射线照射：RD-LPS或托勒林）后，研究胰腺外分泌细胞的超微结构变化。LPS（1 mg/大鼠）可诱导胰腺外分泌细胞线粒体膜的自溶破坏。给予相似剂量的RD-LPS不会产生任何自溶变化。然而，小剂量（100微克/大鼠）的RD-LPS（托勒林）作为预处理可保护由LPS诱导的线粒体自溶破坏。这可能归因于RD-LPS的膜稳定作用。
