Liu Xiaorui, Chen Chunmei, Zheng Yinyu, Zhang Mi, Tong Qingyi, Liu Junjun, Zhou Qun, Wang Jianping, Luo Zengwei, Zhu Hucheng, Zhang Yonghui
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Front Chem. 2018 Dec 7;6:605. doi: 10.3389/fchem.2018.00605. eCollection 2018.
(±)-Peniorthoesters A and B (± and ±), two pairs of unprecedented spiro-orthoester enantiomers with a 1,4,6-trioxaspiro[4. 5]decane-7-one unit, were obtained from . Their structures were determined by spectroscopic methods, X-ray diffraction analyses, and ECD calculations. (±)-Peniorthoesters A and B are the first examples of spiro-orthoester enantiomers, and they represent the first spiro-orthoesters originating from fungi. All compounds showed potential inhibitory activities comparable to dexamethasone against NO production with IC values ranging from 14.2 to 34.5 μM.
从……中获得了（±）-Peniorthoesters A和B（±和±），这是两对具有1,4,6-三氧杂螺[4.5]癸烷-7-酮单元的前所未有的螺环原酸酯对映体。它们的结构通过光谱方法、X射线衍射分析和ECD计算确定。（±）-Peniorthoesters A和B是螺环原酸酯对映体的首个实例，并且它们代表了源自真菌的首个螺环原酸酯。所有化合物均显示出与地塞米松相当的对一氧化氮产生的潜在抑制活性，IC值范围为14.2至34.5μM。
