塔洛萜烯 A-F：海洋来源真菌中的六种新 -萜烯

Talaroterpenoids A-F: Six New -Terpenoids from the Marine-Derived Fungus .

机构信息

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, Collaborative Innovation Center for Guangxi Ethnic Medicine, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, China.

School of Design, Guangxi Normal University, Guilin 541004, China.

出版信息

Mar Drugs. 2024 Oct 18;22(10):475. doi: 10.3390/md22100475.

DOI:10.3390/md22100475

PMID:39452883

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11509394/

Abstract

Six new highly oxidized -terpenoids, including three 3--labdane type diterpenes, talaroterpenoids A-C (-), and three meroterpenoids containing an orthoester group, talaroterpenoids D-F (-), together with five known compounds (- and -), were isolated from the marine-derived fungus . Their chemical structures were elucidated through 1D, 2D NMR, HRESIMS, -based configuration analysis (JBCA), computational ECD calculations, and single-crystal X-ray diffraction analysis. Compounds and contain an unusual 6,20--lactone-bridged scaffold. Compounds and presented inhibitory effects on NO release in lipopolysaccharide (LPS)-induced BV-2 cells with IC values of 11.47 and 11.32 μM, respectively. Talaroterpenoid C () showed moderate antifungal activity against and Steyaert.

摘要

从海洋来源真菌中分离得到 6 个新的高度氧化的 -萜类化合物，包括 3 个 3--劳丹烷型二萜，塔洛萜烯 A-C(-)，和 3 个含有邻酯基的倍半萜，塔洛萜烯 D-F(-)，以及 5 个已知化合物(-和-)。通过 1D、2D NMR、HRESIMS、基于 CD 的构型分析 (JBCA)、计算 ECD 计算和单晶 X 射线衍射分析确定了它们的化学结构。化合物和包含一个不寻常的 6,20--内酯桥接支架。化合物和在脂多糖 (LPS)诱导的 BV-2 细胞中显示出抑制 NO 释放的作用，IC 值分别为 11.47 和 11.32 μM。塔洛萜烯 C()对和具有中等的抗真菌活性。