Talaroterpenoids A-F: Six New -Terpenoids from the Marine-Derived Fungus .

Six new highly oxidized -terpenoids, including three 3--labdane type diterpenes, talaroterpenoids A-C (-), and three meroterpenoids containing an orthoester group, talaroterpenoids D-F (-), together with five known compounds (- and -), were isolated from the marine-derived fungus . Their chemical structures were elucidated through 1D, 2D NMR, HRESIMS, -based configuration analysis (JBCA), computational ECD calculations, and single-crystal X-ray diffraction analysis. Compounds and contain an unusual 6,20--lactone-bridged scaffold. Compounds and presented inhibitory effects on NO release in lipopolysaccharide (LPS)-induced BV-2 cells with IC values of 11.47 and 11.32 μM, respectively. Talaroterpenoid C () showed moderate antifungal activity against and Steyaert.