Massachusetts Mental Health Center, Public Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Massachusetts Mental Health Center, Public Psychiatry Division, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; The Royal's Institute of Mental Health Research, University of Ottawa, Ottawa, ON, Canada.
Neurobiol Dis. 2019 Nov;131:104353. doi: 10.1016/j.nbd.2018.12.013. Epub 2018 Dec 22.
Schizophrenia is associated with cognitive deficits across all stages of the illness (i.e., high risk, first episode, early and chronic phases). Identifying the underlying neurobiological mechanisms of these deficits is an important area of scientific inquiry. Here, we selectively review evidence regarding the pattern of deficits across the developmental trajectory of schizophrenia using the five cognitive domains identified by the Research Domain Criteria (RDoC) initiative. We also report associated findings from neuroimaging studies. We suggest that most cognitive domains are affected across the developmental trajectory, with corresponding brain structural and/or functional differences. The idea of a common mechanism driving these deficits is discussed, along with implications for cognitive treatment in schizophrenia.
精神分裂症与疾病的所有阶段（即高风险、首发、早期和慢性阶段）的认知缺陷有关。确定这些缺陷的潜在神经生物学机制是科学研究的一个重要领域。在这里，我们使用研究领域标准（RDoC）计划确定的五个认知领域，选择性地综述了与精神分裂症发展轨迹中的缺陷模式相关的证据。我们还报告了神经影像学研究的相关发现。我们认为，大多数认知领域在整个发展轨迹中都受到影响，同时伴有相应的大脑结构和/或功能差异。我们还讨论了一个共同的机制来驱动这些缺陷的观点，以及它对精神分裂症认知治疗的影响。
