CCL11、CCL24 和 CCL26 与原发性胆汁性胆管炎的关系。
Association of CCL11, CCL24 and CCL26 with primary biliary cholangitis.
机构信息
Department of General Surgery, Huangyan Hospital of Wenzhou Medical University, Taizhou First People's Hospital, Taizhou, Zhejiang, China.
Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University, Shanghai, China.
出版信息
Int Immunopharmacol. 2019 Feb;67:372-377. doi: 10.1016/j.intimp.2018.12.026. Epub 2018 Dec 22.
BACKGROUND
CCL11, CCL24 and CCL26 are potent chemokines for eosinophils. Since there has been no study reporting the association serum CCL11, CCL24 and CCL26 with fibrotic progression of PBC, the aim of this study is to explore the association.
METHODS
One hundred and eight PBC patients, 52 patients with chronic hepatitis B (CHB) and 50 healthy controls (HC) were recruited. The sera were detected for CCL11, CCL24 and CCL26 using multiplex immunoassay. Other laboratory indicators were routinely measured. PBC was divided into four stages according to Scheuer's classification.
RESULTS
Serum CCL11, CCL24 and CCL26 levels were significantly higher in PBC patients than those with CHB and HC (P < 0.05). The ROC analyses showed that all of the three CCLs performed well for identification of PBC (all P< or =0.001). The multiple linear regression analysis showed an independent relationship of CCL26 with APRI and FIB-4 in PBC patients, but no relationship of CCL11 and CCL24 with fibrotic indicators. Additionally, serum CCL11 and CCL26 were negatively correlated with histological stage of PBC, while serum CCL24 showed no statistical correlation.
CONCLUSION
Serum CCL11, CCL24 and CCL26 are upregulated in PBC. CCL11 and CCL26 are associated with fibrotic progression of PBC, but CCL24 is not.
背景
CCL11、CCL24 和 CCL26 是嗜酸性粒细胞的有效趋化因子。由于尚无研究报告血清 CCL11、CCL24 和 CCL26 与 PBC 的纤维化进展有关，因此本研究旨在探讨其相关性。
方法
招募了 108 名 PBC 患者、52 名慢性乙型肝炎（CHB）患者和 50 名健康对照者（HC）。采用多重免疫分析法检测血清 CCL11、CCL24 和 CCL26。常规检测其他实验室指标。根据 Scheuer 分类，将 PBC 分为四期。
结果
PBC 患者血清 CCL11、CCL24 和 CCL26 水平明显高于 CHB 患者和 HC（P<0.05）。ROC 分析显示，这三种 CCLs 均能很好地识别 PBC（均 P<0.001）。多元线性回归分析显示，CCL26 与 PBC 患者的 APRI 和 FIB-4 呈独立相关，而 CCL11 和 CCL24 与纤维化指标无相关性。此外，血清 CCL11 和 CCL26 与 PBC 的组织学分期呈负相关，而血清 CCL24 则无统计学相关性。
结论
血清 CCL11、CCL24 和 CCL26 在 PBC 中上调。CCL11 和 CCL26 与 PBC 的纤维化进展有关，而 CCL24 则无关。
Zotero 插件