Department of Psychiatry, University of British Columbia, Mood Disorders Centre of Excellence, Djavad Mowafaghian Centre for Brain Health, Vancouver, British Columbia, Canada.
Department of Psychiatry, University of British Columbia, Mood Disorders Centre of Excellence, Djavad Mowafaghian Centre for Brain Health, Vancouver, British Columbia, Canada; Department of Physical Medicine and Rehabilitation, Spaulding Rehabilitation Hospital, Harvard Medical School, and Home Base, A Red Sox Foundation and Massachusetts General Hospital Program, Boston, MA, United States.
Psychiatry Res. 2019 Feb;272:144-148. doi: 10.1016/j.psychres.2018.12.062. Epub 2018 Dec 10.
Patients with major depressive disorder (MDD) often report that cognitive difficulties, such as memory problems or poor concentration, interfere with their work functioning. We examined the association between self-reported cognitive complaints and work functioning in employed patients with MDD treated with desvenlafaxine. A sample of 36 adult outpatients with MDD completed subjective cognition (British Columbia Cognitive Complaints Inventory [BC-CCI]) and functioning scales (Sheehan Disability Scale [SDS]; Lam Employment Absence and Productivity Scale [LEAPS]; and Health and Work Performance Questionnaire [HPQ]) before and after 8 weeks of open-label treatment with flexibly-dosed desvenlafaxine (50-100 mg/day). Multiple regression analyses were used to assess the relationship between subjective cognitive measures and work functioning scales. Patients showed significant improvements in clinical, cognitive, and work functioning measures following treatment with desvenlafaxine. A predictive association was found between the BC-CCI and both the SDS and LEAPS, but not with the HPQ, when adjusted for depression severity. Self-report cognitive questionnaires can provide useful information to monitor changes in cognitive functioning over time and to predict improvement in work functioning outcomes.
患有重度抑郁症（MDD）的患者常报告称认知困难（如记忆力问题或注意力不集中）会影响他们的工作能力。我们研究了在接受去甲文拉法辛治疗的患有 MDD 的在职患者中，自我报告的认知问题与工作能力之间的关联。一个由 36 名成年 MDD 门诊患者组成的样本在接受为期 8 周的开放性去甲文拉法辛（50-100mg/天）治疗前后完成了主观认知（不列颠哥伦比亚认知抱怨量表 [BC-CCI]）和功能量表（Sheehan 残疾量表 [SDS]；Lam 就业缺勤和生产力量表 [LEAPS]；以及健康和工作表现问卷 [HPQ]）。使用多元回归分析来评估主观认知测量与工作功能量表之间的关系。在接受去甲文拉法辛治疗后，患者的临床、认知和工作功能指标均显著改善。在调整抑郁严重程度后，发现 BC-CCI 与 SDS 和 LEAPS 均呈预测性关联，但与 HPQ 无关。自我报告的认知问卷可以提供有用的信息来监测认知功能随时间的变化，并预测工作功能结果的改善。
