Department of Biochemistry, College of Natural Sciences, Kangwon National University, Chunchon 24341, Korea.
Institute of New Frontier Research, College of Medicine, Hallym University, Chunchon 24251, Korea.
Int J Mol Sci. 2018 Dec 23;20(1):51. doi: 10.3390/ijms20010051.
Histone modification is associated with resistance to anti-cancer drugs. Epigenetic modifications of histones can regulate resistance to anti-cancer drugs. It has been reported that histone deacetylase 3 (HDAC3) regulates responses to anti-cancer drugs, angiogenic potential, and tumorigenic potential of cancer cells in association with cancer-associated genes (CAGE), and in particular, a cancer/testis antigen gene. In this paper, we report the roles of microRNAs that regulate the expression of HDAC3 and CAGE involved in resistance to anti-cancer drugs and associated mechanisms. In this review, roles of HDAC3-miRNAs-CAGE molecular networks in resistance to anti-cancer drugs, and the relevance of HDAC3 as a target for developing anti-cancer drugs are discussed.
组蛋白修饰与抗癌药物耐药性有关。组蛋白的表观遗传修饰可以调节抗癌药物的耐药性。据报道，组蛋白去乙酰化酶 3（HDAC3）与癌症相关基因（CAGE）一起调节抗癌药物的反应、血管生成潜力和癌细胞的致瘤潜力，特别是癌症/睾丸抗原基因。在本文中，我们报告了调节与抗癌药物耐药性相关的 HDAC3 和 CAGE 表达的 microRNAs 的作用及其相关机制。在这篇综述中，讨论了 HDAC3-miRNAs-CAGE 分子网络在抗癌药物耐药性中的作用，以及 HDAC3 作为抗癌药物开发靶点的相关性。
Zotero 插件
