Bayram Serkan, Mert Lezgin, Anarat Fikret Berkan, Chodza Mechmed, Ergin Ömer Naci
Department of Orthopedic and Traumatology, Istanbul University, Istanbul Faculty of Medicine, Istanbul, Turkey.
J Orthop Case Rep. 2018 May-Jun;8(3):71-73. doi: 10.13107/jocr.2250-0685.1116.
Multiple bone fractures in a newborn can be associated with osteogenesis imperfect (OI). OI is a rare genetic disorder that causes Type I collagen synthesis disturbance results in bone fragility.
We present a female newborn which had numerous fractures of the humerus, bilateral clavicle, and bilateral femur. Her delivery was at 36 weeks gestation by spontaneous vaginal delivery. She had has not any pathological symptom at 2 weeks after birth, the patient had a fracture of the humerus, bilateral clavicle, and femur without any trauma. Genetic analysis of the patient was reported and OI diagnosed. The patient was followed up for 8 months with regularly and without any complication.
Multiple fractures with OI in an infant after birth may require an accurate orthopedic plan for diagnosing and treatment.
新生儿多发性骨折可能与成骨不全（OI）有关。OI是一种罕见的遗传性疾病，会导致I型胶原蛋白合成紊乱，从而导致骨骼脆弱。
我们报告一名女性新生儿，其肱骨、双侧锁骨和双侧股骨多处骨折。她在妊娠36周时通过自然阴道分娩。出生后2周她没有任何病理症状，在没有任何外伤情况下出现了肱骨、双侧锁骨和股骨骨折。对该患者进行了基因分析，诊断为OI。对患者进行了8个月的定期随访，未出现任何并发症。
出生后婴儿患有OI的多发性骨折可能需要准确的骨科诊疗方案来进行诊断和治疗。
