使用壳聚糖的碱性溶液制备海藻酸钠与壳聚糖的聚电解质复合凝胶。
Preparation of polyelectrolyte complex gel of sodium alginate with chitosan using basic solution of chitosan.
机构信息
Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35, Yamate, Suita, Osaka 564-8680, Japan.
Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35, Yamate, Suita, Osaka 564-8680, Japan.
出版信息
Int J Biol Macromol. 2019 Apr 1;126:54-59. doi: 10.1016/j.ijbiomac.2018.12.195. Epub 2018 Dec 22.
In general, chitosan (CS) cannot be dissolved in basic solution, however it was found that the basic CS solution could be prepared using sodium hydrogen carbonate. NMR measurements revealed that CS was transformed to carbamate ion in the basic condition (around pH 8) thus it acts as anionic nature in this medium. Based on this discovery, novel polyelectrolyte complex (PEC) gel of sodium alginate (SA) and CS was successfully prepared using a basic CS solution and d-gluconolactone (GDL). Gel formation mechanism was explained based on the H and C NMR measurement results. It was found that the elastic modulus of SA/CS PEC gel were higher than that of SA/Chitosan oligomer gel. Moreover, the SA/CS PEC gel was the homogeneous gel and become over 7000 Pa for maximum of elastic modulus. This novel PEC gel will be used in several applications such as tissue engineering, drug delivery system and fuel cell.
一般来说，壳聚糖（CS）不能溶解在碱性溶液中，但人们发现可以使用碳酸氢钠来制备碱性 CS 溶液。NMR 测量表明，CS 在碱性条件下（约 pH 8）转化为氨基甲酸盐离子，因此在该介质中具有阴离子性质。基于这一发现，使用碱性 CS 溶液和 D-葡萄糖酸内酯（GDL）成功制备了海藻酸钠（SA）和 CS 的新型聚电解质复合物（PEC）凝胶。根据 H 和 C NMR 测量结果解释了凝胶形成机制。结果发现，SA/CS PEC 凝胶的弹性模量高于 SA/壳聚糖低聚物凝胶。此外，SA/CS PEC 凝胶是均匀凝胶，弹性模量最高可达 7000 Pa 以上。这种新型 PEC 凝胶将用于组织工程、药物传递系统和燃料电池等多个领域。
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