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Age-Related Changes in Gut Microbiota Alter Phenotype of Muscularis Macrophages and Disrupt Gastrointestinal Motility.

作者信息

Becker Laren, Spear Estelle T, Sinha Sidhartha R, Haileselassie Yeneneh, Habtezion Aida

机构信息

Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Stanford, California.

Division of Gastroenterology and Hepatology, Department of Medicine, Stanford University, Stanford, California.

出版信息

Cell Mol Gastroenterol Hepatol. 2019;7(1):243-245.e2. doi: 10.1016/j.jcmgh.2018.09.001. Epub 2018 Sep 17.

DOI:10.1016/j.jcmgh.2018.09.001
PMID:30585161
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6305843/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8da/6305843/4d846f3275a7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8da/6305843/fc1a93af3472/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8da/6305843/4d846f3275a7/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8da/6305843/fc1a93af3472/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a8da/6305843/4d846f3275a7/gr2.jpg

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J Exp Med. 2018 Feb 5;215(2):441-458. doi: 10.1084/jem.20170057. Epub 2017 Dec 22.
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Aged Gut Microbiota Contributes to Systemical Inflammaging after Transfer to Germ-Free Mice.衰老的肠道微生物群转移到无菌小鼠后会导致全身性炎症衰老。
Front Immunol. 2017 Nov 2;8:1385. doi: 10.3389/fimmu.2017.01385. eCollection 2017.
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Age-Associated Microbial Dysbiosis Promotes Intestinal Permeability, Systemic Inflammation, and Macrophage Dysfunction.
术后胃排空延迟：肠道微生物群可能起作用？
Front Cell Infect Microbiol. 2024 Aug 13;14:1449530. doi: 10.3389/fcimb.2024.1449530. eCollection 2024.
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Efficient enzyme-free method to assess the development and maturation of the innate and adaptive immune systems in the mouse colon.高效的酶免方法评估小鼠结肠固有和适应性免疫系统的发育和成熟。
Sci Rep. 2024 May 14;14(1):11063. doi: 10.1038/s41598-024-61834-5.
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Muscularis macrophages controlled by NLRP3 maintain the homeostasis of excitatory neurons.肌层巨噬细胞受 NLRP3 调控，维持兴奋性神经元的内稳态。
Int J Biol Sci. 2024 Apr 15;20(7):2476-2490. doi: 10.7150/ijbs.91389. eCollection 2024.
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Microbial sensing in the intestine.肠道中的微生物感应。
Protein Cell. 2023 Nov 8;14(11):824-860. doi: 10.1093/procel/pwad028.
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Age-dependent Microglial Disease Phenotype Results in Functional Decline in Gut Macrophages.年龄依赖性小胶质细胞疾病表型导致肠道巨噬细胞功能衰退。
Gastro Hep Adv. 2023;2(2):261-276. doi: 10.1016/j.gastha.2022.09.006. Epub 2022 Sep 29.
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Revisiting Metchnikoff: Age-related alterations in microbiota-gut-brain axis in the mouse.重新审视梅契尼科夫：小鼠中与年龄相关的微生物群-肠道-大脑轴的改变。
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Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality.果蝇衰老过程中微生物群组成的明显变化会损害肠道功能并导致死亡。
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