[Genetic analysis of mitochondrial rho-mutability in Saccharomyces yeasts. V. Isolation and mapping of nuclear mutation srm5, which simultaneously reduces the rho-mutability and mitotic stability of chromosomes].

A nuclear UV-induced srm5 mutation has been isolated which leads to pronounced decrease in spontaneous rho- mutability. Also, this mutation renders yeast n+1 disomes significantly less stable and changes the cell shape. The srm5 mutation has been mapped in the right arm of chromosome II at 10.3 cM from the tyr1 towards the centromere.