[酿酒酵母中线粒体rho-变异性的遗传分析。II. 第四条染色体的二体性与自发rho-变异性]
[Genetic analysis of the mitochondrial rho-mutability in Saccharomyces. II. Disomy for chromosome IV and spontaneous rho-mutability].
作者信息
Devin A B, Koltovaia N A, Cheremukhina N I
出版信息
Genetika. 1986 Oct;22(10):2408-15.
PMID:3539698
Abstract
The disomy for chromosome IV in the strains studied led to: reduction in the red pigmentation of ade1 mutant colonies; a decrease in spontaneous rho- mutant frequency, and impairment of sporulation in hybrids descended from disomic parents. The nuclear srm1 mutation decreasing the spontaneous rho- mutability promoted the spontaneous extra chromosome loss in the disomics for chromosome IV. This result suggests a close connection between the spontaneous rho- mutability and mitotic chromosome stability.
摘要
在所研究的菌株中，第四条染色体的二体性导致：ade1突变菌落的红色色素沉着减少；自发的rho-突变频率降低，以及来自二体亲本的杂交种中孢子形成受损。降低自发rho-突变性的核srm1突变促进了第四条染色体二体中的自发额外染色体丢失。这一结果表明自发rho-突变性与有丝分裂染色体稳定性之间存在密切联系。
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