Benotti J R
Department of Medicine, University of Massachusetts Medical School, Worcester 01605.
Invest Radiol. 1988 Nov;23 Suppl 2:S366-73. doi: 10.1097/00004424-198811002-00010.
Although all contrast media that are used in ventriculography and coronary arteriography have some adverse effects, clinical and laboratory experiences with nonionic contrast media have provided evidence of the lower toxicity and better tolerability associated with these agents. A review of comparative studies of nonionic and ionic contrast media is presented. The nephrotoxic and cardiotoxic effects of ionic contrast agents are discussed. The advantages of the nonionic agent, iohexol, are outlined, and guidelines for its use are suggested.
尽管用于脑室造影和冠状动脉造影的所有造影剂都有一些不良反应，但非离子型造影剂的临床和实验室经验已证明这些药物具有较低的毒性和更好的耐受性。本文对非离子型和离子型造影剂的比较研究进行了综述。讨论了离子型造影剂的肾毒性和心脏毒性作用。概述了非离子型造影剂碘海醇的优点，并提出了其使用指南。
