Liu Shuai, Xu Liang, Wei Yu
School of Chemistry and Chemical Engineering/Key Laboratory for Green Processing of Chemical Engineering of Xin-jiang Bingtuan , Shihezi University , Shihezi 832003 , China.
J Org Chem. 2019 Feb 1;84(3):1596-1604. doi: 10.1021/acs.joc.8b02548. Epub 2019 Jan 9.
The pot-economic synthesis of N, N'-diarylindazol-3-ones has been developed using readily available isatoic anhydrides, aryl amines, and aryl boronic acids. A Cu-catalyzed oxidative C-N cross-coupling and dehydrogenative N-N formation sequence under an air atmosphere affords indazol-3-one derivatives in good to excellent yields. Such process merges well with the preceding decarboxylative amination reaction, resulting in a more modular and straightforward approach.
利用容易获得的异吲哚酮酸酐、芳基胺和芳基硼酸，开发了N，N'-二芳基吲唑-3-酮的一锅法经济合成。在空气气氛下，铜催化的氧化C-N交叉偶联和脱氢N-N形成序列以良好至优异的产率提供吲唑-3-酮衍生物。该过程与之前的脱羧胺化反应很好地结合，从而产生了一种更具模块化和直接的方法。
