Yano Yuka, Kuga Takayuki, Harada Takasuke, Sano Fumiho, Inokuchi Toshihiro, Fujii Yasuhiro
Dept. of Surgery, Nagato General Hospital.
Gan To Kagaku Ryoho. 2018 Dec;45(12):1775-1777.
Therapy-related leukemia(TRL)is a distinctive clinical syndrome that occurs after exposure to chemotherapy or radiotherapy. We report a case of suspected TRLafter chemotherapy in a patient with breast cancer. A 61-year-old woman underwent total mastectomy and sentinel lymph node biopsy(negative)for her breast cancer. Histopathologic analysis showed invasive ductal carcinoma, pStage I. Her subtype histology was Luminal B-type, and postoperative adjuvant chemotherapy and endocrine therapy were administered. Four years after chemotherapy, a blood examination showed pancytopenia. Bone marrow examination showed acute promyelocytic leukemia. She was treated with chemotherapy and achieved complete remission. Breast cancer provides long-term survival after treatment. Attention should be paid to the occurrence of TRLin breast cancer surveillance.
治疗相关白血病（TRL）是一种在接触化疗或放疗后出现的独特临床综合征。我们报告一例乳腺癌患者化疗后疑似TRL的病例。一名61岁女性因乳腺癌接受了全乳切除术和前哨淋巴结活检（结果为阴性）。组织病理学分析显示为浸润性导管癌，p分期为I期。她的组织学亚型为Luminal B型，术后接受了辅助化疗和内分泌治疗。化疗四年后，血液检查显示全血细胞减少。骨髓检查显示为急性早幼粒细胞白血病。她接受了化疗并实现了完全缓解。乳腺癌治疗后可实现长期生存。在乳腺癌监测中应注意TRL的发生。
