Center for Musculoskeletal Surgery, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 13353 Berlin, Germany.
Julius Wolff Institute for Biomechanics and Musculoskeletal Regeneration, Charité-Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, 13353 Berlin, Germany.
Int J Mol Sci. 2018 Dec 26;20(1):83. doi: 10.3390/ijms20010083.
Osteoporosis represents the most common bone disease worldwide and results in a significantly increased fracture risk. Extrinsic and intrinsic factors implicated in the development of osteoporosis are also associated with delayed fracture healing and impaired bone regeneration. Based on a steadily increasing life expectancy in modern societies, the global implications of osteoporosis and impaired bone healing are substantial. Research in the last decades has revealed several molecular pathways that stimulate bone formation and could be targeted to treat both osteoporosis and impaired fracture healing. The identification and development of therapeutic approaches modulating bone formation, rather than bone resorption, fulfils an essential clinical need, as treatment options for reversing bone loss and promoting bone regeneration are limited. This review focuses on currently available and future approaches that may have the potential to achieve these aims.
骨质疏松症是全球最常见的骨骼疾病，会显著增加骨折风险。在骨质疏松症的发展过程中涉及的外在和内在因素也与骨折愈合延迟和骨再生受损有关。基于现代社会中人们预期寿命的稳步增加，骨质疏松症和骨愈合受损的全球影响是巨大的。在过去几十年的研究中，已经发现了几个刺激骨形成的分子途径，这些途径可以作为治疗骨质疏松症和骨愈合受损的靶点。确定和开发调节骨形成而不是骨吸收的治疗方法满足了一个基本的临床需求，因为逆转骨质流失和促进骨再生的治疗选择是有限的。这篇综述重点介绍了目前可能有潜力实现这些目标的方法。
