人类血清催乳素水平与感染之间的关系。
The relation of serum prolactin levels and infection in humans.
作者信息
Mohammadpour A, Keshavarz H, Mohebali M, Salimi M, Teimouri A, Shojaee S
机构信息
Department of Medical Parasitology and Mycology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran,
Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
Int J Gen Med. 2018 Dec 20;12:7-12. doi: 10.2147/IJGM.S188525. eCollection 2019.
BACKGROUND
is an intracellular protozoan parasite distributed worldwide. Although the infection is benign in immunocompetent individuals, it is life threatening and complicated in immunocompromised patients and fetuses of pregnant women who received their first exposure to during the pregnancy. Prolactin (PRL) is a hormone that is secreted by the pituitary gland, and it is confirmed that it plays a role in the immune system. The present study was carried out to assess the possible relation between serum PRL levels and infection frequency in human.
METHODS
In this cross-sectional study, 343 serum samples (240 from women and 103 from men) were collected from individuals who were referred for PRL checking in laboratories of Karaj, Iran. Blood samples were collected, and sera were separated and analyzed for the detection of anti- IgG antibody by ELISA method. The levels of PRL were measured by Roche Elecsys 2010 analyzer, electrochemiluminescence technology.
RESULTS
Of 343 sera, 110 samples (32%) consisting of samples from 42 men and 68 women had anti- IgG antibody. The prevalence of infection in women with high PRL levels was lower than that in the comparison group with normal levels of PRL and the relationship between these two parameters was statistically significant (=0.016). In women with hyperprolactinemia, by increasing of PRL levels, the prevalence of infection was reduced.
CONCLUSION
The results of the current study confirmed the previous studies based on immunoregulatory role of PRL and indicated that high levels of PRL could be related to seronegativity in women.
背景
是一种分布于全球的细胞内原生动物寄生虫。虽然该感染在免疫功能正常的个体中是良性的，但在免疫功能低下的患者以及孕期首次接触该寄生虫的孕妇的胎儿中，它会危及生命且情况复杂。催乳素（PRL）是一种由垂体分泌的激素，并且已证实它在免疫系统中发挥作用。本研究旨在评估血清PRL水平与人类感染频率之间的可能关系。
方法
在这项横断面研究中，从伊朗卡拉季实验室因检查PRL而前来就诊的个体中收集了343份血清样本（240份来自女性，103份来自男性）。采集血样，分离血清，并通过ELISA法分析检测抗IgG抗体。PRL水平通过罗氏Elecsys 2010分析仪采用电化学发光技术进行测定。
结果
在343份血清中，110份样本（32%）含有抗IgG抗体，其中包括42名男性和68名女性的样本。PRL水平高的女性中感染的患病率低于PRL水平正常的对照组，这两个参数之间的关系具有统计学意义（P = 0.016）。在高催乳素血症的女性中，随着PRL水平的升高，感染的患病率降低。
结论
本研究结果证实了先前基于PRL免疫调节作用的研究，并表明高PRL水平可能与女性血清学阴性有关。
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