Raj P P, Aschhoff M, Lilly L, Balakrishnan S
St. Thomas Hospital and Leprosy Centre, Chettupattu, Tamil Nadu.
Indian J Lepr. 1988 Jul;60(3):400-6.
The half time of disappearance of dapsone and monoacetyl dapsone and the acetylator phenotype of the leprosy patients who harboured dapsone sensitive and dapsone resistant M. leprae was assessed in 27 subjects. Sixteen patients were rapid acetylators, five were slow and six were intermediate acetylators. The mean T 1 1/2 lives of dapsone (30.26 +/- 11.0) and monoacetyl dapsone (31.11 +/- 12.0) were also studied in the above patients. The percentage of different acetylators in both resistant and sensitive groups were similar showing no correlation between the emergence of drug resistance and the phenotype of the patient. The mean time of disappearance of DDS and MAD in the different acetylators did not show significant difference. The ratios of MAD/DDS in an individual at 3, 6 or 24 hours after the dose were similar. The mean T 1 1/2 lives of DDS and MAD in resistant and sensitive patients also showed no difference. Neither T 1 1/2 lives of DDS or MAD nor the acetylator phenotype seem to influence the emergence of dapsone resistance.
在27名受试者中评估了氨苯砜和单乙酰氨苯砜的消除半衰期以及携带对氨苯砜敏感和耐药麻风杆菌的麻风病患者的乙酰化表型。16名患者为快速乙酰化者，5名是慢速乙酰化者，6名是中间型乙酰化者。还对上述患者的氨苯砜（30.26 +/- 11.0）和单乙酰氨苯砜（31.11 +/- 12.0）的平均半衰期进行了研究。耐药组和敏感组中不同乙酰化者的百分比相似，表明耐药性的出现与患者的表型之间没有相关性。不同乙酰化者中氨苯砜和单乙酰氨苯砜的平均消失时间没有显著差异。给药后3、6或24小时个体中氨苯砜单乙酰氨苯砜的比值相似。耐药和敏感患者中氨苯砜和单乙酰氨苯砜的平均半衰期也没有差异。氨苯砜或单乙酰氨苯砜的半衰期以及乙酰化表型似乎都不会影响氨苯砜耐药性的出现。
