Callow A D
Tufts University School of Medicine, New England Medical Center Hospitals, Boston, Massachusetts.
Int Angiol. 1988 Jul-Sep;7(3):246-53.
Hyperplasia at the graft host artery anastomosis is probably the commonest cause of intermediate and late failure and is seen most frequently and most severely in small diameter grafts. An arterial substitute with an internal diameter of less than 4 mm which can maintain patency in a flow rate not in excess of 50 cc per minute is the sought after graft. Contributing to the formation of this hyperplastic lesion are activated platelets, activated monocytes, dedifferentiated endothelial cells, and probably other elements which under these circumstances of activation produce smooth muscle cell and other mitogens. A multidisciplinary approach utilizing the information from polymer chemistry, fluid engineering, cell biology, and the essentials of thrombosis is required.
移植血管与宿主动脉吻合处的增生可能是中期和晚期失败最常见的原因，在小口径移植血管中最为常见且最为严重。内径小于4毫米且能在每分钟不超过50立方厘米的流速下维持通畅的动脉替代物是人们所追求的移植血管。促成这种增生性病变形成的因素有活化的血小板、活化的单核细胞、去分化的内皮细胞，以及可能在这些活化情况下产生平滑肌细胞和其他促有丝分裂原的其他成分。需要采用一种多学科方法，综合聚合物化学、流体工程、细胞生物学以及血栓形成要点等方面的信息。
